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Krüppel样因子7的研究进展

陈月婵, 魏虹, 张志威

石河子大学医学院基础医学系；石河子大学医学院第一附属医院科研科，石河子 832000

摘要

Krüppel样因子7 (Krüppel-like factor 7, KLF7)是一个羧基端具有3个高度保守的C2H2锌指结构的转录因子，因最早发现在成人多种组织中广泛表达，又被叫做普遍存在的Krüppel样因子(ubiquitous KLF, UKLF)。功能研究表明转录因子KLF7在神经系统发育、脂肪组织形成和2型糖尿病发生中发挥重要作用。此外，KLF7对神经外胚层和中胚层的发育以及干细胞的全能性也具有一定的调控作用。近年来的表观遗传学和整合基因组学研究提示，KLF7可能在弥漫型胃腺癌和心血管疾病的发生和治疗中发挥功能。本文从遗传特性、蛋白质结构和基因功能三个方面综述了转录因子KLF7的研究进展。

关键词： Krüppel样因子7; 遗传相关; 分子结构; 基因功能

分类号：Q71;Q75

[Research progress of Krüppel-like factor 7.] [Article in Chinese]

CHEN Yue-Chan, WEI Hong, ZHANG Zhi-Wei

Department of Basic Medicine, School of Medicine, Shihezi University； Office of Scientific Research, The First Affiliated Hospital of School of Medicine, Shihezi University, Shihezi 832000, China

Abstract

Krüppel-like factor 7 (KLF7), a member of Krüppel-like transcription factors (KLFs), also known as ubiquitous Krüppel- like factor (UKLF), is ubiquitously expressed in various tissues of adult human beings. Genetics reports showed that the genetic polymorphism of KLF7 is associated with obesity, type 2 diabetes, mental development in human beings; and KLF7 methylation is associated with the development of diffuse gastric cancer (gastric adenocarcinoma). In addition, some genomics reports suggested that KLF7 is one of the key transcription factors in the regulatory networks of serum markers change during the cardiovascular disease. The function studies showed that KLF7 is involved in the regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cells maintenance. This review summarizes the research progress of KLF7 in genetic characteristics, protein structure and gene function.

Key words: Krüppel-like factor 7; genetic association; molecular structure; gene function

收稿日期：2016-05-02　　录用日期：2016-06-29

通讯作者：张志威　　E-mail: zzwneau@163.com

引用本文：

陈月婵, 魏虹, 张志威. Krüppel样因子7的研究进展[J]. 生理学报 2016; 68 (6): 809-815.

CHEN Yue-Chan, WEI Hong, ZHANG Zhi-Wei. [Research progress of Krüppel-like factor 7.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (6): 809-815 (in Chinese with English abstract).