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神经调节蛋白4生物学功能的研究进展

杨帆, 李晓南^*

南京医科大学附属儿童医院儿童保健科，南京 210008

摘要

神经调节蛋白4 (neuregulin 4, NRG4)是一种含有表皮生长因子(epidermal growth factor, EGF)类似区域的蛋白分子，主要在棕色脂肪细胞中表达和分泌。NRG4通过与EGF的受体ErbB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4)特异性结合，发挥其刺激细胞增殖、抑制细胞凋亡以及改善细胞能量代谢等生理学功能。越来越多的证据表明NRG4在上皮细胞相关疾病、心血管疾病、多部位肿瘤以及糖脂代谢相关疾病中发挥重要的作用，因此有可能成为多种疾病潜在的治疗靶点。

关键词： 神经调节蛋白4; ErbB4; 生物学功能

分类号：R33

[Research progress of neuregulin 4 biological function.] [Article in Chinese]

Yang Fan, LI Xiao-Nan^*

Department of Child Health Care, Children’s Hospital of Nanjing Medical University, Nanjing 210008, China

Abstract

Neuregulin 4 (NRG4) is a kind of protein containing epidermal growth factor (EGF)-like domains, mainly expressed and secreted by brown adipocytes. It specifically activates EGF receptor ErbB4 (v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) to stimulate cell proliferation, inhibit apoptosis and improve energy metabolism of cells. Increasing evidence has shown that NRG4 plays an important role in epithelial cell-related diseases, cardiovascular diseases, tumors and glycolipid metabolic diseases, and therefore it could be a potential therapeutic target of some diseases.

Key words: neuregulin 4; ErbB4; biological function

收稿日期：2016-09-05　　录用日期：2017-02-22

通讯作者：李晓南　　E-mail: xnli@njmu.edu.cn

引用本文：

杨帆, 李晓南. 神经调节蛋白4生物学功能的研究进展[J]. 生理学报 2017; 69 (3): 351-356.

Yang Fan, LI Xiao-Nan. [Research progress of neuregulin 4 biological function.] [Article in Chinese]. Acta Physiol Sin 2017; 69 (3): 351-356 (in Chinese with English abstract).