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哺乳动物中雌激素对铁代谢的影响

杨晓, 许曼曼, 王俊, 谢俊霞

青岛大学临床医学院2013级9班，青岛 266071；青岛大学医学院生理学教研室，山东省神经相关疾病重点实验室，山东省神经退变疾病协同创新中心，国家生理学重点培育学科，青岛 266071

摘要

雌激素是一种类固醇激素，主要由卵巢产生，通过与受体结合来发挥其生物学效应并对机体代谢产生影响。研究者发现在动物体内雌激素水平的变化同时也伴随着机体内铁的储量的变化。近几年雌激素反应元件(estrogen response element, ERE)的发现提示雌激素能够直接参与哺乳动物铁代谢的调节。本文就雌激素参与机体各个系统铁代谢的调节及相关机制做了综述，以期为雌激素的临床用药提供指导。雌激素与铁代谢关系密切，其具体调节机制还有待进一步深入探讨。

关键词： 雌激素; 铁; 雌激素反应原件

分类号：Q493.9

Effect of estrogen on iron metabolism in mammals

YANG Xiao, XU Man-Man, WANG Jun, XIE Jun-Xia

Class 9, Grade 2013, Medical College of Qingdao University, Qingdao 266071, China； Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders, Shandong Provincial Collaborative Innovation Center for Neurodegenerative Disorders and State Key Disciplines: Physiology (in incubation), Medical College of Qingdao University, Qingdao 266071, China

Abstract

Estrogen is a steroid hormone produced mainly by the ovaries. It combines with the nuclear receptors to exert the biological effects influencing the metabolism of body. Elevated levels of estrogen are often associated with altered iron levels in mammals. Furthermore, the findings of estrogen response element (ERE) have demonstrated that estrogen affects iron metabolism directly in peripheral tissues. In this review, we will briefly summarize the effect of estrogen on iron metabolism in mammals, and discuss recent progress in the mechanisms of estrogen on some iron related proteins in order to provide guidance for clinical use of estrogen. Estrogen and iron metabolism are closely related, but the exact regulatory mechanisms still need further exploration.

Key words: Estrogen; iron; estrogen response element

收稿日期：2016-02-25　　录用日期：2016-06-29

通讯作者：谢俊霞　　E-mail: jxiaxie@public.qd.sd.cn

引用本文：

杨晓, 许曼曼, 王俊, 谢俊霞. 哺乳动物中雌激素对铁代谢的影响[J]. 生理学报 2016; 68 (5): 637-643.

YANG Xiao, XU Man-Man, WANG Jun, XIE Jun-Xia. Effect of estrogen on iron metabolism in mammals. Acta Physiol Sin 2016; 68 (5): 637-643 (in Chinese with English abstract).