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自噬在神经干细胞中的研究进展

焦倩, 杜希恂, 谢俊霞, 姜宏^*

青岛大学生理学教研室，青岛 266071

摘要

神经干细胞(neural stem cells, NSCs)移植是神经退行性疾病新的治疗途径，但移植细胞在动物模型的存活率和分化率需进一步提高。因此了解调节NSCs存活和死亡的机制，对于发展以干细胞移植为基础的治疗方法至关重要。自噬是维持细胞稳态的重要途径，可通过影响NSCs的存活和增殖等生物学行为进而改变NSCs的命运。本文就自噬和NSCs关系做一综述，从存活、凋亡、增殖和分化及其相关机制等方面展示自噬对NSCs命运的影响。

关键词： 自噬; 神经干细胞; 凋亡; 增殖; 分化

分类号：Q189

[An overview on autophagy in neural stem cells.] [Article in Chinese]

JIAO Qian, DU Xi-Xun, XIE Jun-Xia, JIANG Hong^*

State Key Disciplines: Physiology, Medical College of Qingdao University, Qingdao, 266071, China

Abstract

Neural stem cells (NSCs) offer great promise for the treatment of multiple neurodegenerative diseases. However, the survival and differentiation rates of grafted cells in the host brain need to be enhanced. In this regard, understanding of the underlying mechanism of NSCs survival and death is of great importance for the implications of stem cell-based therapeutic application in the treatments of neurological disorders. Autophagy is a conserved proteolytic mechanism required for maintaining cellular homeostasis, which can affect NSCs fate through regulating their biological behaviors, such as survival and proliferation. In this mini-review, we will summarize the effects of autophagy on NSCs fate including survival, apoptosis, proliferation and differentiation, as well as the underlying mechanisms.

Key words: autophagy; neural stem cells; apoptosis; proliferation; differentiation

收稿日期：2016-02-25　　录用日期：2016-04-15

通讯作者：姜宏　　E-mail: hongjiang@qdu.edu.cn

引用本文：

焦倩, 杜希恂, 谢俊霞, 姜宏. 自噬在神经干细胞中的研究进展[J]. 生理学报 2016; 68 (5): 649-654.

JIAO Qian, DU Xi-Xun, XIE Jun-Xia, JIANG Hong. [An overview on autophagy in neural stem cells.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (5): 649-654 (in Chinese with English abstract).