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心外膜与心脏的修复再生

夏禹, 周勇^*

中国科学院干细胞重点实验室，中国科学院上海生命科学研究院/上海交通大学医学院健康科学研究所，上海 200031

摘要

心外膜是心脏的重要组成部分之一，它在心脏的发育过程中起到了关键的作用。随着研究的深入，心外膜在心脏损伤后的修复再生中的作用也渐渐被人们所了解。心脏受损后，心外膜分泌了多种信号因子调控心肌细胞的增殖以及新血管的生成。同时，在损伤刺激下，心外膜分化为多潜能的心外膜衍生细胞，这些细胞在心脏的损伤修复中至关重要。本文将从心外膜的作用、心外膜相关的信号因子和通路以及其潜在的临床应用等方面的研究进展进行综述，为未来心外膜和心脏再生的更深入研究提供参考。

关键词： 心外膜; 心脏损伤修复; 心脏再生

分类号：Q46；R331

[The epicardium in cardiac repair and regeneration.] [Article in Chinese]

XIA Yu, ZHOU Yong^*

Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences &； Shanghai Jiao Tong University School of Medicine, Shanghai 200031, China

Abstract

Epicardium is one of the important components of the heart and plays a critical role in cardiogenesis. Moreover, further studies have shown that epicardium contributes to post-injury heart regeneration. After heart injury, epicardium secretes various signaling factors, regulating the cardiomyocyte proliferation and neovascularization. In addition, epicardium differentiates into many kinds of cells which take part in the heart repair in response to heart damage. In this review, we summarize recent progress on epicardial function, related signaling pathways and the potential clinical application, and provide a reference for future studies in epicardium and heart regeneration.

Key words: epicardium; heart injury repair; heart regeneration

收稿日期：2016-03-28　　录用日期：2016-06-26

通讯作者：周勇　　E-mail: zhouyong@sibs.ac.cn

引用本文：

夏禹, 周勇. 心外膜与心脏的修复再生[J]. 生理学报 2016; 68 (4): 525-533.

XIA Yu, ZHOU Yong. [The epicardium in cardiac repair and regeneration.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (4): 525-533 (in Chinese with English abstract).