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miR-24对内皮细胞功能的调节及其在心血管疾病发生发展中的作用

陈伟, 欧和生^*

广西医科大学药学院，南宁 530021

摘要

microRNA-24 (miR-24)属于miR-23~27~24家族，高表达于血管内皮细胞(vascular endothelial cells, VECs)，并调控VECs多种特异性基因的表达。研究显示，miR-24参与VECs增殖、凋亡、血管形成、炎性反应和分化等功能的调节，而它的表达异常与VECs功能紊乱及损伤密切相关，且参与心血管疾病的发生和发展。本文就miR-24参与调控VECs功能的分子机制，及其在心血管疾病发生发展过程中的作用作一综述。

关键词： 血管内皮细胞; miR-24; 血管内皮细胞功能; 心血管疾病

分类号：Q753

[Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease.] [Article in Chinese]

CHEN Wei, OU He-Sheng^*

College of Pharmacy, Guangxi Medical University, Nanning 530021, China

Abstract

microRNA-24 (miR-24) belongs to miR-23~27~24 cluster. It is highly expressed in vascular endothelial cells (VECs), and plays an important role in the regulation of VECs specific gene expression. Recent studies indicate that miR-24 is involved in the regulation of VECs function such as proliferation, apoptosis, angiopoiesis, inflammation, and differentiation. The dysregulation of miR-24 is associated with dysfunction or even damage of VECs, and contributes to the development of cardiovascular disease. In this review, we summarized the molecular mechanisms of miR-24 in regulating VECs function, and its role and importance during the development of cardiovascular disease.

Key words: Vascular endothelial cell; miR-24; VECs function; cardiovascular disease

收稿日期：2015-12-04　　录用日期：2016-03-09

通讯作者：欧和生　　E-mail: hsou01@yahoo.com

引用本文：

陈伟, 欧和生. miR-24对内皮细胞功能的调节及其在心血管疾病发生发展中的作用[J]. 生理学报 2016; 68 (2): 201-206.

CHEN Wei, OU He-Sheng. [Regulation of miR-24 on vascular endothelial cell function and its role in the development of cardiovascular disease.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (2): 201-206 (in Chinese with English abstract).