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抵抗素在胰岛素抵抗中的作用机制及其受体信号通路研究进展

任毅, 左之才^*, 万涛梅

四川农业大学动物医学院临床兽医系动物疫病与人类健康重点实验室，雅安 625014

摘要

抵抗素是近年来在体内发现的一种新的脂肪细胞因子。研究显示，抵抗素可以通过多种途径促发胰岛素抵抗，诱导2型糖尿病(type 2 diabetes mellitus, T2DM)的发生，并且可以经由不同的信号通路介导机体炎性反应。抵抗素作为联系炎症与代谢的信号因子，有望为治疗胰岛素抵抗和T2DM提供新思路。然而，由于尚未在体内找到抵抗素的特异性受体，其在体内一系列调节活动的具体机制目前仍不清楚。本文就目前关于抵抗素在胰岛素抵抗调节机制及其受体信号通路的研究进展作一综述。

关键词： 抵抗素; 受体 ; 信号通路

分类号：R363

Resistin: It’s role in insulin resistance and mechanism of action

REN Yi, ZUO Zhi-Cai^*, WAN Tao-Mei

Key Laboratory of Animal Disease and Human Health, College of Veterinary Medicine, Sichuan Agricultural University, Yaan 625014, China

Abstract

Resistin is a new adipokine found in vivo in recent years. Recent studies have indicated that resistin contributes to the development of insulin resistance and type 2 diabetes mellitus (T2DM) and mediates inflammatory reaction via different signal pathways. As a signal factor between inflammation and metabolism, resistin is expected to provide new insights for the treatment of insulin resistance and T2DM. However, because specific receptor of resistin has not been identified in the body so far, the molecular mechanism of resistin actions is still unclear. In this article, we review the latest progresses of resistin study, especially the role of resistin in insulin resistance and its signaling mechanism.

Key words: resistin; receptor ; signaling pathway

收稿日期：2015-08-24　　录用日期：2015-10-14

通讯作者：左之才　　E-mail: zzcjl@126.com

引用本文：

任毅, 左之才, 万涛梅. 抵抗素在胰岛素抵抗中的作用机制及其受体信号通路研究进展[J]. 生理学报 2016; 68 (1): 65-74.

REN Yi, ZUO Zhi-Cai, WAN Tao-Mei. Resistin: It’s role in insulin resistance and mechanism of action. Acta Physiol Sin 2016; 68 (1): 65-74 (in Chinese with English abstract).