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多巴胺受体与谷氨酸NMDA受体/A型γ-氨基丁酸受体的相互作用

陈慧英, 韦廷佳, 翁敬锦, 覃江圆, 黄喜, 苏纪平^*

广西医科大学第一附属医院耳鼻咽喉头颈外科，南宁 530021

摘要

A型γ-氨基丁酸受体(type A γ-aminobutyric acid receptor, GABAAR)和N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor, NMDAR)分别是中枢神经系统中主要的抑制性和兴奋性受体。共同表达在突触区的受体之间在功能上相互调节、相互影响，即受体相互作用。中枢神经系统中GABAAR和NMDAR之间既可表现为相互抑制，也可表现为相互增强，受体相互作用的深层次机制尚不明确，目前认为可能的机制有：(1) 通过第二信使作用；(2) 通过受体转运作用；(3) 受体间直接接触作用；(4)通过第三方受体介导的作用等。多巴胺是大脑中含量最丰富的儿茶酚胺类神经递质，其相应的受体，多巴胺受体(dopamine receptor, DR)可以激活多种信号转导途径。DR分别与NMDAR/GABAAR的相互作用已有不少报道，然而由受体介导受体相互作用的机制仍鲜有研究，提示研究中枢神经系统中DR介导NMDAR与GABAAR相互作用具有非常重要的意义。本文就DR与NMDAR、GABAAR相互作用的相关机制及研究进展作一综述，以期为进一步阐明DR介导的NMDAR与GABAAR相互作用提供基础参考。

关键词： 受体相互作用; 多巴胺受体; GABAA受体; NMDA受体

分类号：Q426；R338.2

[Interactions between dopamine receptor and NMDA/type A γ-aminobutyric acid receptors.] [Article in Chinese]

CHEN Hui-Ying, WEI Tin-Jia, WENG Jing-Jin, QIN Jiang-Yuan, HUANG Xi, SU Ji-Ping^*

Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning 530000, China

Abstract

Type A γ-aminobutyric acid receptors (GABAAR) and N-methyl-D-aspartate receptors (NMDAR) are the major inhibitory and excitatory receptors in the central nervous system, respectively. Co-expression of the receptors in the synapse may lead to functional influence between receptors, namely receptor interaction. The interactions between GABAAR and NMDAR can be either positive or negative. However, the mechanisms of interaction between the two receptors remain poorly understood, and potential mechanisms include (1) through a second messenger; (2) by receptors trafficking; (3) by direct interaction; (4) by a third receptor- mediation. Dopamine is the most abundant catecholamine neurotransmitter in the brain, and its receptors, dopamine receptors (DR) can activate multiple signaling pathways. Earlier studies on the interaction between DR and GABAAR/NMDAR have shown some underlying mechanisms, suggesting that DR could mediate the interaction between GABAAR and NMDAR. This paper summarized some recent progresses in the studies of the interaction between DR and NMDAR/GABAAR, providing a further understanding on the interaction between NMDAR and GABAAR mediated by DR.

Key words: receptor interaction; dopamine receptor; GABAA receptor; NMDA receptor

收稿日期：2015-10-12　　录用日期：2016-01-29

通讯作者：苏纪平　　E-mail: ymsu2@126.com

引用本文：

陈慧英, 韦廷佳, 翁敬锦, 覃江圆, 黄喜, 苏纪平. 多巴胺受体与谷氨酸NMDA受体/A型γ-氨基丁酸受体的相互作用[J]. 生理学报 2016; 68 (2): 185-193.

CHEN Hui-Ying, WEI Tin-Jia, WENG Jing-Jin, QIN Jiang-Yuan, HUANG Xi, SU Ji-Ping. [Interactions between dopamine receptor and NMDA/type A γ-aminobutyric acid receptors.] [Article in Chinese]. Acta Physiol Sin 2016; 68 (2): 185-193 (in Chinese with English abstract).