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肾上腺髓质素在炎性疼痛和吗啡耐受中的作用

黄冰晴, 洪炎国

福建师范大学生命科学学院，福建省发育和神经生物学重点实验室，福州 350108

摘要

背根神经节(dorsal root ganglia, DRG)和脊髓背角中痛介质(pronociceptive mediator)的增加是炎性疼痛与阿片耐受发生的重要病理机制。肾上腺髓质素(adrenomedullin, AM)属于降钙素基因相关肽(calcitonin gene-related peptide, CGRP)家族，是新近证实的痛介质。研究表明，炎症和重复应用吗啡时，DRG和脊髓背角中AM含量和释放都增加。鞘内给予AM受体阻断剂AM22-52能抑制炎性疼痛与吗啡耐受，表明DRG和脊髓背角中AM受体活动的增加参与炎性疼痛和吗啡耐受发生的病理过程。本文综述了最近有关研究进展，讨论了AM参与这两类疾患发生的神经学机制。

关键词： 肾上腺髓质素; 吗啡耐受; 炎性疼痛; 背根神经节; 脊髓背角

分类号：Q426

[Involvement of adrenomedullin in the pathogenesis of inflammatory pain and morphine tolerance.] [Article in Chinese]

HUANG Bing-Qing, HONG Yanguo

Provincial Key Laboratory of Developmental Biology and Neuroscience, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China

Abstract

The increase of pronociceptive mediators in the dorsal root ganglia (DRG) and spinal dorsal horn is an important mechanism in the pathogenesis of inflammatory pain and opioid tolerance. Adrenomedullin (AM) belongs to calcitonin gene-related peptide (CGRP) family and has been recently demonstrated to be a pain-related peptide. It has also been shown that the expression and release of AM are increased in the DRG and spinal dorsal horn during inflammation and repeated use of morphine. Intrathecal administration of the selective AM receptor antagonist AM22-52 abolishes inflammatory pain and morphine tolerance, suggesting that enhanced AM receptor signaling in the DRG and spinal dorsal horn contributes to the induction of inflammatory pain and morphine tolerance. The present review highlights the recent developments regarding the involvement of AM in these two disorders. The neurological mechanisms of AM’s actions are also discussed.

Key words: Adrenomedullin; morphine tolerance; inflammatory pain; dorsal root ganglia; spinal dorsal horn

收稿日期：2015-03-12　　录用日期：2015-04-17

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引用本文：

黄冰晴, 洪炎国. 肾上腺髓质素在炎性疼痛和吗啡耐受中的作用[J]. 生理学报 2015; 67 (4): 431-436.

HUANG Bing-Qing, HONG Yanguo. [Involvement of adrenomedullin in the pathogenesis of inflammatory pain and morphine tolerance.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (4): 431-436 (in Chinese with English abstract).