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Wnt5a与炎症信号在炎症性疾病中的交叉互动

刘征, 吴洪涛, 倪亚光, 尹艳桃, 李顺祥, 廖端芳, 覃丽

南华大学药物药理研究所，衡阳 4210002；中南大学湘雅二医院，长沙 41001；湖南中医药大学药学院，长沙 410208

摘要

Wnt5a是一种分泌型糖蛋白，是高度保守的Wnts蛋白家族成员之一。在生物体内Wnts家族参与调控细胞命运、胚胎发育、细胞增殖、迁移和分化等重要过程。研究表明，Wnt5a的表达调控及其信号转导与炎症应答密切相关，提示Wnt5a及其信号通路在炎症性疾病的发生、发展中发挥着重要作用。本文从Wnt5a与炎症因子、炎症信号转导通路以及炎症疾病等方面进行阐述和展望，旨在为以Wnt5a为靶点进行炎症性疾病的防治提供理论依据。

关键词： Wnt5a; 炎症; 炎症因子; 信号通路

分类号：Q71

[Crosstalk between Wnt5a and inflammatory signaling in inflammation.] [Article in Chinese]

LIU Zheng, WU Hong-Tao, NI Ya-Guang, YIN Yan-Tao, LI Shun-Xiang, LIAO Duan-Fang, QIN Li

Institute of Pharmacology and Pharmacy, University of South China, Hengyang 421001, China； The Second Xiangya Hospital, Central South University, Changsha 410011,China； School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, China

Abstract

Wnt5a belongs to the large WNT family of cysteine-rich secreted glycoproteins, which is involved in multiple signaling pathways that regulate a variety of cellular processes, including cell motility, proliferation differentiation and so on during development. The regulation and signaling transduction of Wnt5a have been reported to closely relate to inflammatory response, which indicates that Wnt5a plays a critical role in the occurrence and development of inflammatory diseases. In this review, we summarized data on Wnt5a and its signaling pathway, as well as their involvement in inflammatory response. Further comprehensive understanding of the function and relationship between Wnt5a and inflammatory response would help us to develop novel diagnostic and therapeutic strategies for prevention and treatment of inflammatory diseases.

Key words: Wnt5a; inflammation; inflammatory factors; signaling pathway

收稿日期：2015-03-16　　录用日期：2015-06-02

通讯作者：覃丽　　E-mail: lqin1011@126.com

引用本文：

刘征, 吴洪涛, 倪亚光, 尹艳桃, 李顺祥, 廖端芳, 覃丽. Wnt5a与炎症信号在炎症性疾病中的交叉互动[J]. 生理学报 2015; 67 (4): 437-445.

LIU Zheng, WU Hong-Tao, NI Ya-Guang, YIN Yan-Tao, LI Shun-Xiang, LIAO Duan-Fang, QIN Li. [Crosstalk between Wnt5a and inflammatory signaling in inflammation.] [Article in Chinese]. Acta Physiol Sin 2015; 67 (4): 437-445 (in Chinese with English abstract).