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p62与蛋白降解途径的研究进展

刘诗濛, 董越娟, 刘彬

河南大学护理学院神经生物学研究所；附属淮河医院消化内科，开封 475000

摘要

p62是一种多功能泛素结合蛋白，参与泛素蛋白酶体系统(ubiquitin-proteasome system, UPS)和自噬-溶酶体系统两种蛋白降解过程。p62作为一种信号转导途径中的支架和适配子蛋白，其分子结构中的多个功能结构域可与其它蛋白质相互作用，介导多种细胞功能，特别是在细胞的选择性自噬和细胞抗氧化反应中发挥重要作用，因而p62与许多疾病的发病机制密切相关。本文主要综述p62的结构特征及其与UPS和自噬的相互关系，旨在为相关领域的研究提供参考。

关键词： p62; 蛋白降解; 泛素; 蛋白酶体; 自噬

分类号：R37

Progress of study on p62 and protein degradation pathways

LIU Shi-Meng, DONG Yue-Juan, Liu Bin

Institute of Neurobiology, College of Nursing； Department of Gastroenterology, Huaihe Clinical College, Henan University, Kaifeng 475000, China

Abstract

The p26, a multifunctional ubiquitin-binding protein, has been proposed to be involved in protein degradation as a component within the ubiquitin-proteasome and autophagy-lysosome systems. As a scaffolding protein with several different kinds of protein-protein interaction domains, p62 mediates various cellular functions. Importantly, p62 plays a critical role in cell’s selective autophagy and oxidative stress response, which are associated with the pathogenesis of several human diseases. In this review, we describe the structure of p62 and the mechanism of connection between p62 and ubiquitin-proteasome system/autophagy, so as to provide some perspectives on p62 research.

Key words: p62;protein degradation;ubiquitin;proteasome；autophagy ;

收稿日期：2014-05-22　　录用日期：2014-07-29

通讯作者：刘彬　　E-mail: lbgood5912@sina.com

引用本文：

刘诗濛, 董越娟, 刘彬. p62与蛋白降解途径的研究进展[J]. 生理学报 2015; 67 (1): 45-58.

LIU Shi-Meng, DONG Yue-Juan, Liu Bin. Progress of study on p62 and protein degradation pathways. Acta Physiol Sin 2015; 67 (1): 45-58 (in Chinese with English abstract).