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大鼠前庭核团中与线性运动相关的神经发育状况

马俊伟, 黎振航, 韩磊, 布志高, 岑国欣, 陈应城

香港大学李嘉诚医学院生理学系；生物化学系；心、脑、内分泌及抗衰老研究中心，香港

摘要

中枢前庭系统拥有处理从内耳传入外周感觉信息的能力，这令动物能够在三维空间中感知头部朝向，并同时能调节运动姿势。在发育中，前庭核团神经元的电生理特性发生很大的改变；膜的兴奋性程度随着年龄而增长，这一特性是与这些神经元逐渐增加发放频率以及加强放电模式规律性同步发生的。前庭核团神经元对感知水平和垂直线性运动的编码能力在发育过程中也做了非常大的完善。这些发育中的前庭核团神经元表面受体，比如谷氨酸受体，亦会随着动物成熟过程做出表达调整，用以调控突触传递可塑性的效率，进而影响这些神经元在神经回路中处理空间编码的能力。总而言之，前庭核团神经元的这些特征有助脑部于发育过程中建立三维空间坐标的能力。

关键词： 空间识别; 前庭核团; 耳石器官; 线性加速; 发育

分类号：Q426;R338.4

Development of neural correlates of linear motion in the rat vestibular nucleus

Chun-Wai Ma, Chun-Hong Lai, Lei Han, Francisco Paulo De Nogueira Botelho, Daisy Kwok-Yan Shum, Ying-Shing Chan

Departments of 1Physiology and Biochemistry, and Research Centre of Heart, Brain, Hormone and Healthy Aging, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China

Abstract

The capability of the central vestibular system in utilizing cues arising from the inner ear determines the ability of animals to acquire the sense of head orientations in the three-dimensional space and to shape postural movements. During development, neurons in the vestibular nucleus (VN) show significant changes in their electrophysiological properties. An age-dependent enhancement of membrane excitability is accompanied by a progressive increase in firing rate and discharge regularity. The coding of horizontal and vertical linear motions also exhibits developmental refinement in VN neurons. Further, modification of cell surface receptors, such as glutamate receptors, of developing VN neurons are well-orchestrated in the course of maturation, thereby regulating synaptic efficacy and spatial coding capacity of these neurons in local circuits. Taken together, these characteristic features of VN neurons contribute to developmental establishment of space-centered coordinates within the brain.

Key words: spatial recognition; vestibular nucleus; otolith organs; linear acceleration; development

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通讯作者：黎振航　　E-mail: chlaib@hku.hk

引用本文：

马俊伟, 黎振航, 韩磊, 布志高, 岑国欣, 陈应城. 大鼠前庭核团中与线性运动相关的神经发育状况[J]. 生理学报 2014; 66 (1): 37-46.

Chun-Wai Ma, Chun-Hong Lai, Lei Han, Francisco Paulo De Nogueira Botelho, Daisy Kwok-Yan Shum, Ying-Shing Chan. Development of neural correlates of linear motion in the rat vestibular nucleus. Acta Physiol Sin 2014; 66 (1): 37-46 (in Chinese with English abstract).