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维生素D对心血管系统保护作用的研究进展

董京辉, 刘志伟, 黄少玲, 黄聿^*

Institute of Vascular Medicine, Li Ka Shing Institute of Health Sciences, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China

摘要

维生素D是机体内维持钙磷代谢稳定的重要物质，临床用于治疗骨质疏松以及甲状旁腺功能亢进。有证据显示日晒减少以及摄入不足导致的维生素D缺乏症与心血管疾病以及慢性肾脏疾病紧密相关。维生素D激活其受体，在辅助因子的作用下形成转录复合物，从而直接或间接调节机体内约3%的基因转录。肾素、肿瘤坏死因子、基质金属蛋白酶等都受其调控。基础及临床实验都已证明维生素D对心血管系统有保护作用。它可保护心脏功能、降低血压、改善血管内皮功能、抑制氧化应激、降低肾素-血管紧张素活性等。本文将就维生素D及其受体激动剂对心血管系统的保护作用以及分子机制的最新研究进展作一简单综述。

关键词： 维生素D; 维生素D受体; 肾素-血管紧张素系统; 氧化应激; 心血管功能

分类号：R331

Cardiovascular benefits of vitamin D

Jinghui Dong, Chi Wai Lau, Siu Ling Wong, Yu Huang^*

香港中文大学心脑血管医学研究所，李嘉诚健康科学研究所及深圳研究院，香港

Abstract

Vitamin D is essential for maintaining calcium and phosphate homeostasis, and vitamin D analogues have been prescribed to treat osteoporosis and hyperparathyroidism. Emerging evidence suggests that cardiovascular and chronic kidney diseases are closely associated with vitamin D deficiency resulting from either decreased sunshine exposure or inadequate intake. Vitamin D is through stimulating vitamin D receptor to form a transcriptional complex with cofactors to modulate approximately 3% gene transcription. For example, renin, matrix metalloprotease, and tumor necrosis factor-α are regulated by vitamin D. Both experimental and clinical studies support the health benefits of vitamin D in the cardiovascular system, and such benefits include protecting cardiac function, lowering blood pressure, improving endothelial function, inhibiting oxidative stress, and reducing the activity of renin-angiotensin system. This article will briefly review the cardiovascular benefits of vitamin D and its bioactive analogues and discuss the novel cellular and molecular mechanisms accounting for cardiovascular protection.

Key words: vitamin D; vitamin D receptor; renin-angiotensin system; oxidative stress; cardiovascular function

收稿日期：　　录用日期：

通讯作者：黄聿　　E-mail: yu-huang@cuhk.edu.hk

引用本文：

董京辉, 刘志伟, 黄少玲, 黄聿. 维生素D对心血管系统保护作用的研究进展[J]. 生理学报 2014; 66 (1): 30-36.

Jinghui Dong, Chi Wai Lau, Siu Ling Wong, Yu Huang. Cardiovascular benefits of vitamin D. Acta Physiol Sin 2014; 66 (1): 30-36 (in Chinese with English abstract).