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运动改善胰岛素抵抗与腺苷酸活化蛋白激酶关系的研究进展

李蕾, 李之俊

淮北师范大学体育学院 淮北 235000； 上海体育科学研究所 上海 200030

摘要

腺苷酸活化蛋白激酶(AMP-activated protein kinase, AMPK)广泛存在于骨骼肌、肝脏、胰腺、脂肪组织及中枢神经系统中。作为“细胞能量调节器”，AMPK激活后可通过多种机制改善胰岛素抵抗。本文综述了近年来AMPK (骨骼肌、肝脏和脂肪组织)的运动激活以及AMPK介导运动改善心血管胰岛素敏感性的研究进展，展望了AMPK运动激活的研究前景，旨在为全面了解和明确AMPK在运动干预效应中的重要地位提供理论依据。

关键词： 腺苷酸活化蛋白激酶; 胰岛素抵抗; 运动

分类号：R339.4

[Progress on relationship between exercise improving insulin resistance and AMP-activated protein kinase.] [Article in Chinese]

LI Lei, LI Zhi-Jun

School of Physical Education, Huaibei Normal University, Huaibei 235000, China； Shanghai Research Institute Of Sports Science, Shanghai 200030, China

Abstract

The AMP-activated protein kinase (AMPK) widely exists in skeletal muscle, liver, pancreas, adipose tissue and central nervous system. As a "cellular energy regulator", activation of AMPK can improve insulin resistance in various mechanisms. To overall understand the importance of AMPK in exercise, the article summarized the research progress on AMPK exercise activation in skeletal muscle, liver and adipose tissue as well as exercise improving cardiovascular insulin resistance by AMPK, and looked forward to the study future of AMPK exercise activation.

Key words: AMP-activated protein kinase; insulin resistance; exercise

收稿日期：2013-07-25　　录用日期：2013-11-06

通讯作者：李蕾　　E-mail: lisulei73@aliyun.com

引用本文：

李蕾, 李之俊. 运动改善胰岛素抵抗与腺苷酸活化蛋白激酶关系的研究进展[J]. 生理学报 2014; 66 (2): 231-240.

LI Lei, LI Zhi-Jun. [Progress on relationship between exercise improving insulin resistance and AMP-activated protein kinase.] [Article in Chinese]. Acta Physiol Sin 2014; 66 (2): 231-240 (in Chinese with English abstract).