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内源性大麻素系统在胃肠道的作用

林旭红, 王亚强, 王慧超, 任学群^*, 李永渝^*

1同济大学医学院病理生理教研室，同济大学消化系疾病研究所，上海 200092；2河南大学淮河医院检验科，开封 475000；3河南大学一附院肾内科，开封 475000；4河南大学淮河医院普外科，开封 475000

摘要

植物大麻用于临床已有几千年的历史，在许多胃肠道疾病如呕吐、腹泻、炎症性肠病、肠源性疼痛治疗中发挥重要作用。本文旨在综述内源性大麻素系统的组成及其在胃肠道活动中的调节作用，为进一步研究提供相关信息，并为通过调节胃肠道内源性大麻素系统治疗胃肠道疾病提供新靶点。

关键词： 大麻素; 内源性大麻素系统; 大麻素受体; 内源性配体; 胃肠道功能

分类号：R333.3

[Role of endogenous cannabinoid system in the gut.] [Article in Chinese]

LIN Xu-Hong, WANG Ya-Qiang, WANG Hui-Chao, REN Xue-Qun^*, LI Yong-Yu^*

Department of Pathophysiology, Institute of Digestive Disease, School of Medicine, Tongji University, Shanghai 200092, China； Department of Clinical Laboratory, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, China； Department of Nephrology, First Affiliated Hospital of Henan University, Kaifeng 475000, China； Department of General Surgery, Huaihe Hospital Affiliated to Henan University, Kaifeng 475000, China

Abstract

The plant Cannabis has been used in clinic for centuries, and has been known to be beneficial in a variety of gastrointestinal diseases, such as emesis, diarrhea, inflammatory bowel disease and intestinal pain. In this text, we'll review the components of the endogenous cannabinoid system as well as its role in the regulation of gastrointestinal activities, thus providing relative information for further study. Moreover, modulation of the endogenous cannabinoid system in gastrointestinal tract may provide a useful therapeutic target for gastrointestinal disorders.

Key words: cannabinoids; endogenous cannabinoid system; cannabinoid receptor; endogenous ligands; gastrointestinal function

收稿日期：2013-01-30　　录用日期：2013-04-12

通讯作者：任学群,李永渝　　E-mail: hhyyrxq@126.com, liyongyu@tongji.edu.cn

引用本文：

林旭红, 王亚强, 王慧超, 任学群, 李永渝. 内源性大麻素系统在胃肠道的作用[J]. 生理学报 2013; 65 (4): 451-460.

LIN Xu-Hong, WANG Ya-Qiang, WANG Hui-Chao, REN Xue-Qun, LI Yong-Yu. [Role of endogenous cannabinoid system in the gut.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (4): 451-460 (in Chinese with English abstract).