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Neuritin的研究进展

姚金晶, 梅岩艾

复旦大学生命科学学院，上海 200433

摘要

Neuritin是神经营养因子家族中的一个新成员，其基因cpg15 (candidate plasticity-related gene 15)可由神经活动或神经营养素(neurotrophins, NTs)激活。实验表明neuritin能够促进神经元突起的生长和分支，在神经元可塑性及神经元再生中发挥着重要的作用。近年来的研究证实，neuritin不仅参与神经系统中多项生理功能的调节，还在血管生成以及相关肿瘤的发生中扮演着重要角色。本文将综述neuritin蛋白的翻译表达和调控机理、生物学效用，并围绕neuritin如何发挥其生物活性及目前研究中存在的热点和难点进行讨论。

关键词： 神经突起因子; 神经可塑性; 血管生成; 肿瘤

分类号：R338

[Progress of study on neuritin.] [Article in Chinese]

YAO Jin-Jing, MEI Yan-Ai

Institute of Life Science, Fudan University, Shanghai 200433, China

Abstract

Neuritin is a new member of the neurotrophic factor family, whose gene is named cpg15 (candidate plasticity-related gene 15) and can be activated by neural activity or neurotrophins (NTs). Experiments show that neuritin is able to promote the growth and branching of neurites, and plays an important role in neuronal plasticity and neuronal regeneration. Recent studies have proved that neuritin is not only involved in the regulation of various physiological functions in the nervous system, but also related in angiogenesis and tumorigenesis. Here we review the mechanisms involved in cpg15 expression and regulation, biological effects of neuritin, and how neuritin plays its biological activities. The hot issues and difficulties in the study of neuritin are also discussed.

Key words: neuritin; neural plasticity; angiogenesis; tumor

收稿日期：2013-04-22　　录用日期：2013-07-09

通讯作者：　　E-mail:

引用本文：

姚金晶, 梅岩艾. Neuritin的研究进展[J]. 生理学报 2013; 65 (5): 483-488.

YAO Jin-Jing, MEI Yan-Ai. [Progress of study on neuritin.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (5): 483-488 (in Chinese with English abstract).