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应激诱发抑郁症的细胞因子机制研究进展

彭云丽, 王雯英, 蒋春雷, 王云霞

第二军医大学应激医学研究室，上海 200433；山东省青岛市骨伤科医院关节二科，青岛 266021

摘要

抑郁症是现代社会严重的精神卫生问题，而应激是抑郁症的重要诱发因素。抑郁症发病机制复杂，尚未完全明确。应激诱发抑郁症的机制也有待深入研究。神经内分泌免疫学的飞速发展为应激性抑郁症的病因学研究提供了更广阔的视野。长期慢性应激激活外周及中枢免疫系统，大量炎性介质释放(包括细胞因子)。激活的免疫系统通过与神经系统、神经内分泌系统的相互作用影响抑郁症的进程。细胞因子通过调节单胺类神经递质的合成、代谢与重摄取，引起下丘脑-垂体-肾上腺皮质(hypothalamus-pituitary-adrenal, HPA)轴的过度激活并使其负反馈调节受损，破坏神经形成等机制引发抑郁症。本文将从细胞因子的角度对应激诱发抑郁症机制的研究进展进行综述。

关键词： 应激; 抑郁症; 细胞因子; 5-羟色胺; 下丘脑-垂体-肾上腺皮质(HPA)轴; 神经可塑性

分类号：R74

[Roles of cytokines in stress-induced depression.] [Article in Chinese]

Peng Yun-li, Wang Wen-ying, Jiang Chun-lei, Wang Yun-xia

Lab of Stress Medicine, the Second Military Medical University, Shanghai 200433, China； Department of Joint, Osteo-traumatic Hospital of Qingdao, Qingdao 266021, China

Abstract

Depression is a very common mental health problem in our modern society. Stress is involved in the provocation of depression. The pathogenesis of depressive disorder is still not well known. The development of neuroendocrine immunology opens a new sight for clarification of mechanism underlying stress-induced depression. Chronic stress activates peripheral and central immune systems accompanied with the release of inflammatory mediators, including cytokines. Activated immune system mediates the process of depression through the interaction with neuron system and neuroendocrine system, including regulating the monoamine neurotransmitter system in synthesis, metabolism and reuptake, inducing the overactivation of hypothalamus-pituitary-adrenal (HPA) axis and its negative feedback regulation, and reducing neurogenesis. This present paper reviews the cytokines mechanisms underlying stress-induced depression.

Key words: Stress; depression; cytokine; 5-HT; HPA axis; neural plasticity

收稿日期：2012-07-24　　录用日期：2012-10-06

通讯作者：王云霞　　E-mail: cloudywang66@163.com

引用本文：

彭云丽, 王雯英, 蒋春雷, 王云霞. 应激诱发抑郁症的细胞因子机制研究进展[J]. 生理学报 2013; 65 (2): 229-236.

Peng Yun-li, Wang Wen-ying, Jiang Chun-lei, Wang Yun-xia. [Roles of cytokines in stress-induced depression.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (2): 229-236 (in Chinese with English abstract).