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磷脂酰乙醇胺结合蛋白的信号调节机制及其生物学功能研究进展

边佳明, 吴宁, 李锦

北京军区总医院药理科，北京 100700；军事医学科学院毒物药物研究所，北京 100850

摘要

磷脂酰乙醇胺结合蛋白(phosphatidylethanolamine-binding protein, PEBP)是一个结构上高度保守的胞浆可溶性蛋白。近年的研究显示，在细胞信号转导中，PEBP具有多种生物学功能，包括调节ERK通路、NF-κB通路、G蛋白偶联受体通路等多种重要的信号转导。此外，PEBP在肿瘤领域的临床研究价值也得到了越来越多的支持和认可，其表达水平和多种肿瘤的转移相关。作为一个多功能的信号调节分子，PEBP正在成为多个领域的研究热点。本文就近年来有关PEBP信号调节机制和生物学功能的研究进展做一回顾。

关键词： 磷脂酰乙醇胺结合蛋白; Raf激酶抑制蛋白; ERK; NF-κB; 海马

分类号：R329

[Roles of phosphatidylethanolamine-binding protein in cell signaling and its biological functions.] [Article in Chinese]

BIAN Jia-ming, WU Ning, LI Jin

Department of Pharmacology, Military General Hospital of Beijing PLA, Beijing 100700, China； Institute of Toxicology and Pharmacology, Academy of Military Medical Sciences, Beijing 100850, China

Abstract

Phosphatidylethanolamine-binding protein (PEBP) is a cytoplasm soluble protein with a high conserved structure. It has been approved recently that PEBP is a multifunctional molecule regulating several important cellular signal pathways, including ERK cascade, NF-κB pathway, and signaling of G protein-coupled receptors. Furthermore, the role of PEBP in tumor metastasis also got a comprehensive attention in the field of clinical cancer research. Together, as a signal regulator at multiple paths in cell, PEBP is becoming a new focus in several research fields. This review is aimed to introduce the newest biological progress on PEBP.

Key words: phosphatidylethanolamine-binding protein; Raf kinase inhibitor protein; ERK; NF-κB; hippocampus

收稿日期：2012-08-15　　录用日期：2012-11-09

通讯作者：李锦　　E-mail: jinli9802@163.com

引用本文：

边佳明, 吴宁, 李锦. 磷脂酰乙醇胺结合蛋白的信号调节机制及其生物学功能研究进展[J]. 生理学报 2013; 65 (2): 237-243.

BIAN Jia-ming, WU Ning, LI Jin. [Roles of phosphatidylethanolamine-binding protein in cell signaling and its biological functions.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (2): 237-243 (in Chinese with English abstract).