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从呼气末CO2浓度与动脉血压的关系判断人工呼吸猫的最适肺通气量

李朝义

中国科学院上海生理研究所，上海 200031

摘要

中枢神经系统单细胞记录时需使用人工呼吸的动物,通常用连续监视终末呼出气中的CO2浓度(ET-CO2)作为一个敏感的指标,来控制适当的肺通气量。为了确定一个可靠的ET-CO2标准,我们观察了麻醉和麻痹的猫在不同的肺通气量下ET-CO2和动脉血压(ABP)的关系。结果表明,ABP随着肺通气量的不同而出现明显的改变;然而,当ET-CO2维持在4.0-5.0％范围内时,血压可一直保持在正常水平。根据以上结果,ET-CO2的最佳值应设定为4.5%±0.5%。

关键词： 猫; 动脉血压; 肺通气; 人工呼吸; 二氧化碳

Optimal pulmonary ventilation determined by the relation between end-tidal CO2 and arterial blood pressure in artificially respirated cat

LI CHAO-YI

Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031, China

Abstract

End-tidal CO2 (ET-CO2) provides a continuous and sensitive monitoring of proper pulmonary ventilation in artificially ventilated animals during single unit recordings of the central nervous system. To determine a reliable standard of ET-CO2 in anesthetized and paralyzed animal, the relationship between ET-CO2 and arterial blood pressure (ABP) was observed in cat under different ventilation level. The results showed that ABP changed tremendously with variation in ventilation, but remained constant at a normal level as long as ET-CO2 was maintained within the range between 4.0-5.0%, i.e. optimally at 4.5 +/- 0.5%.

Key words: Cat; arterial blood pressure; pulmonary ventilation; artificial respiration; carbon dioxide

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引用本文：

李朝义. 从呼气末CO2浓度与动脉血压的关系判断人工呼吸猫的最适肺通气量[J]. 生理学报 1992; 44 (6): 597-602.

LI CHAO-YI. Optimal pulmonary ventilation determined by the relation between end-tidal CO2 and arterial blood pressure in artificially respirated cat. Acta Physiol Sin 1992; 44 (6): 597-602 (in Chinese with English abstract).