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Nogo-B的生物学功能

胥武剑, 沈国庆, 李强

第二军医大学附属长海医院呼吸内科，上海 200433；中国人民解放军73676部队，无锡 214162

摘要

Nogo-B是网状蛋白家族4的重要成员，其广泛表达于中枢神经系统及外周组织，其亚细胞定位于细胞内质网及细胞膜。研究显示，Nogo-B主要参与血管损伤、组织修复、再生及炎症过程的调控，并可能在肿瘤细胞凋亡及中枢神经系统疾病中也发挥重要作用。对Nogo-B的结构及其功能的进一步探索，有助于更加深入地了解其在各种疾病中发挥作用的机制。

关键词： Nogo-B; 组织修复; 炎症; 凋亡; 阿尔茨海默病

分类号：Q257

[Biological function of Nogo-B.] [Article in Chinese]

XU Wu-Jian, SHEN Jian-Guo, LI Qiang

Department of Respiratory Disease, Changhai Hospital, Second Military Medical University, Shanghai 200433, China； China People’s Liberation Army 73676, Wuxi 214162, China

Abstract

Nogo-B is a major family member of the reticulon protein family 4. It is widely expressed in the central nervous system and peripheral tissues, and is mainly located in endoplasmic reticulum and cell membrane. Previous studies have revealed that Nogo-B plays a key role in vascular injury, tissue repair and inflammation process. It also may be critical for apoptosis of tumor cells and central diseases. Further investigation of the molecular characteristics and biological function of Nogo-B might be of great help to understand its role in diverse diseases.

Key words: Nogo-B; regeneration;Inflammation; apoptosis; Alzheimer's disease

收稿日期：2013-01-10　　录用日期：2013-03-20

通讯作者：李强　　E-mail: liqressh@yahoo.com.cn

引用本文：

胥武剑, 沈国庆, 李强. Nogo-B的生物学功能[J]. 生理学报 2013; 65 (4): 445-450.

XU Wu-Jian, SHEN Jian-Guo, LI Qiang. [Biological function of Nogo-B.] [Article in Chinese]. Acta Physiol Sin 2013; 65 (4): 445-450 (in Chinese with English abstract).