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电刺激大鼠内侧额叶前皮质对听皮层神经元频率感受野可塑性的调制

杨文伟, 周晓明, 张季平, 孙心德

华东师范大学生命科学学院脑科学研究中心.上海 200062

摘要

该文应用常规电生理学技术,研究电刺激大鼠内侧额叶前皮质(medial prefrontal cortex,mPFC)对初级听皮层神经元频率感受野(receptive field,RF)可塑性的调制。电刺激mPFC,137个听皮层神经元(72.8%)RF可塑性受到影响,其中抑制性调制71个神经元(37.7%),易化性调制66个神经元(35.1%),其余51个神经元(27.2%)不受影响。mPFC的抑制性调制效应表现为,RF的偏移时间延长,恢复时间缩短。相反,mPFC的易化性调制效应表现为,RF的偏移时间缩短,恢复时间延长。电刺激mPFC对RF可塑性的调制与声、电刺激之间的时间间隔有关,最佳时间间隔介于5---30 ms之间。结果提示,大鼠mPFC可以调制听皮层神经元的功能活动,可能参与听觉学习记忆过程。

关键词： 内侧额叶前皮质; 听皮层; 频率感受野; 可塑性; 大鼠

Modulation of frequency receptive field plasticity in rat auditory cortical neurons by electrical stimulation of medial prefrontal cortex

Yang Wenwei, Zhou Xiaoming, Zhang Jiping, Sun Xinde

College of Life Sciences,Research Center for Brain Science,East China Normal University.Shanghai 200062

Abstract

Using conventional electrophysiological technique, we investigated the effects of stimulating medial prefrontal cortex (mPFC) on plasticity of frequency receptive field (RF) of auditory cortex (AC) neurons in rats. When mPFC was electrically stimulated, the RF plasticity of 51 (29.2%) neurons was not affected; the RF plasticity of 137 neurons (72.8%) was either inhibited (71 neurons, 37.7%) or facilitated (66 neurons, 35.1%). The modulation of mPFC on RF plasticity was dependent upon the time interval between acoustic and electrical stimuli. The best interval time that produced optimal modulation (inhibition or facilitation) ranged from 5 to 30 ms. The inhibitory modulation of mPFC prolonged RF shifting time course and shortened RF recovery time course. Conversely, the facilitatory modulation of mPFC shortened RF shifting time course and prolonged RF recovery time course. Our results suggest that the mPFC may affect the plasticity of functional activity of AC neurons, and also may participate in the process of auditory learning and memory.

Key words: medial prefrontal cortex;auditory cortex;frequency receptive field;plasticity;Rat

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引用本文：

杨文伟, 周晓明, 张季平, 孙心德. 电刺激大鼠内侧额叶前皮质对听皮层神经元频率感受野可塑性的调制[J]. 生理学报 2007; 59 (6): 784-790.

Yang Wenwei, Zhou Xiaoming, Zhang Jiping, Sun Xinde. Modulation of frequency receptive field plasticity in rat auditory cortical neurons by electrical stimulation of medial prefrontal cortex. Acta Physiol Sin 2007; 59 (6): 784-790 (in Chinese with English abstract).