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细胞黏附和突触发生

陈功, 吴霞, Sebnem T

宾夕法尼亚州立大学生物学系,Huck生命科学研究所,宾夕法尼亚州 16802

摘要

突触是神经网络中神经细胞间相互连接的基本工作单位。突触的分子构建是一个引人入胜的问题，数十年来一直吸引着科学家们的注意。冯德培和许多其他科学家早期在神经肌肉接头领域做出了开创性的研究工作。至今，神经肌肉接头仍是一个杰出的突触标本，为作者研究中枢神经系统的突触形成铺平了道路。近期的研究又有新的亮点，发现一组细胞黏附分子具有很强的突触发生作用，使中枢突触形成的分子机制更加明朗。该文综述了这些表达在非神经细胞里能引起中枢突触形成的细胞黏附分子的功能与特性。

关键词： 突触发生; 细胞黏附; 突触组装

Cell adhesion and synaptogenesis

Chen Gong, Wu Xia, Sebnem T

Department of Biology, The Huck Institutes of Life Sciences, The Pennsylvania State University, University Park, PA 16802

Abstract

Synapses are inter-neuronal connections that are fundamental working units in neural networks. How synapses are molecularly constructed is a fascinating question, which attracted scientists' attention for many decades. Neuromuscular junction, a field pioneered by Te-Pei FENG and many others, has been an excellent model for studying synaptogenesis and paved the way for our understanding of the synapse formation in the central nervous system. Recent studies shed new light on the molecular mechanisms of central synapse formation by discovering a group of cell adhesion molecules exerting potent synaptogenic effects. This review will focus on those cell adhesion molecules which can induce central synapse formation when expressed in non-neuronal cells.

Key words: synaptogenesis;cell adhesion;synapse assembly

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引用本文：

陈功, 吴霞, Sebnem T. 细胞黏附和突触发生[J]. 生理学报 2007; 59 (6): 697-706.

Chen Gong, Wu Xia, Sebnem T. Cell adhesion and synaptogenesis. Acta Physiol Sin 2007; 59 (6): 697-706 (in Chinese with English abstract).