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神经肌肉接头研究世纪回顾

Lu Ju, Lichtman J W

哈佛大学分子与细胞生物学系.马萨诸塞州 02138

摘要

神经肌肉接头作为突触解剖、生理和发育的模型已被研究了一个多世纪。成像技术提供了诸多关于神经肌肉接头的信息，其中一些技术是专为观察该突触的结构和功能而发展起来的。该文回顾了神经肌肉接头研究中几个重要方面的发展史，包括其结构、N型乙酰胆碱受体的分布、突触小泡释放，以及神经肌肉接头的发育。

关键词： 神经肌肉接头; 成像技术; N型乙酰胆碱受体; 突触小泡释放; 发育

Imaging the neuromuscular junction over the past centuries

Lu Ju, Lichtman J W

Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138

Abstract

The neuromuscular junction （NMJ） has been studied for over a century as a model system for synaptic anatomy, physiology and development. Much of our knowledge of the NMJ has been obtained through imaging techniques, some of which were developed particularly to visualize this synapse's structure and function. In this paper we review the historical development of research on some key aspects of the NMJ, including its structure, nicotinic acetylcholine receptor distribution, the process of synaptic vesicle release, and its development.

Key words: Neuromuscular junction;imaging technique;nicotinic acetylcholine receptor;synaptic vesicle release;development

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引用本文：

Lu Ju, Lichtman J W. 神经肌肉接头研究世纪回顾[J]. 生理学报 2007; 59 (6): 683-696.

Lu Ju, Lichtman J W. Imaging the neuromuscular junction over the past centuries. Acta Physiol Sin 2007; 59 (6): 683-696 (in Chinese with English abstract).