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心肌内源性保护研究中的若干问题与展望

王慷慨, 肖献忠

中南大学湘雅医学院病理生理学系.湖南,长沙 410008

摘要

自上世纪80年代中期Murry及Currie等分别发现缺血预适应(ischemic preconditioning, IPC)与热休克反应(heat shockresponse, HSR)具有明显的心肌保护作用以来,有关心肌内源性保护作用的研究引起了学术界的广泛关注。经过20多年的大量研究,心肌内源性保护研究已在多方面取得了进展,积累了丰富的研究经验,建立了基本的理论框架,其中以IPC和热休克蛋白(heat shock proteins, HSPs)的研究最为引人注目。但基于问题本身的复杂性,目前在心肌内源性保护机制研究中还存在许多待解决的问题。该文拟就IPC、HSPs、心肌内源性保护研究模型与研究策略等问题进行阐述,并对上述领域未来的研究方向进行分析和展望。

关键词： 心肌; 缺血预适应; 热休克蛋白; 基因组学

Endogenous myocardial protection: present questions and prospects

Wang Kangkai, Xiao Xianzhong

Department of Pathophysiology,Xiangya School of Medicine,Central South University.Changsha 410008,Hunan

Abstract

Since the findings of Murry and Currie et al. that ischemic preconditioning （IPC） and heat shock response （HSR） could protect evidently myocardium against ischemia-reperfusion injury in the middle of 1980s, endogenous myocardial protection has drawn widespread attentions. A great quantity of studies completed during the past 25 years made much progress in endogenous myocardial protection. Abundant research experiences have been accumulated and a basic theoretical framework has been established in this field. However, there are still many questions need to be solved. In this review, we focused on clarifying some hot questions and important future directions in IPC, heat shock proteins （HSPs）, research models and strategies in endogenous myocardial protection.

Key words: Myocardium;ischemic preconditioning;Heat shock proteins;genomics

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引用本文：

王慷慨, 肖献忠. 心肌内源性保护研究中的若干问题与展望[J]. 生理学报 2007; 59 (5): 635-642.

Wang Kangkai, Xiao Xianzhong. Endogenous myocardial protection: present questions and prospects. Acta Physiol Sin 2007; 59 (5): 635-642 (in Chinese with English abstract).