过刊浏览

同型半胱氨酸在心血管疾病中的免疫调节作用

戴晶, 王宪

北京大学医学部生理学与病理生理学系.北京 100083

摘要

高同型半胱氨酸血症是动脉粥样硬化的独立危险因子,但是其致病机制尚未完全阐明。该文将从体液免疫、单核巨噬细胞以及T细胞活性等几方面归纳总结同型半胱氨酸在心血管疾病中的免疫调节作用。同型半胱氨酸可以诱导单核细胞和T细胞分泌趋化因子和细胞因子,还可以直接刺激B细胞增殖及IgG分泌。此外,该文还总结了高同型半胱氨酸致炎作用的细胞内机制。同型半胱氨酸可以直接或间接导致氧化应激或者内质网应激,还可以降低一氧化氮的生物活性,影响包括{sl S}--腺苷蛋氨酸和{sl S}--腺苷同型半胱氨酸的水平,从而导致心血管疾病的发生。

关键词： 同型半胱氨酸; 炎症; 心血管疾病

Immunoregulatory effects of homocysteine on cardiovascular diseases

Dai Jing, Wang Xian

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University.Beijing 100083

Abstract

Hyperhomocysteinemia (HHcy) has been recognized as an independent risk factor for atherosclerosis for more than 30 years, but the mechanisms by which HHcy leads to atherosclerosis are not well fully understood. In this review, we will summarize the immunoregulatory effects of homocysteine on cardiovascular diseases from humoral immunity, monocyte/macrophage and T lymphocyte activity. Homocysteine can induce chemokine and cytokine secretion in monocytes and T lymphocytes and also directly stimulate B lymphocyte proliferation and IgG secretion. In addition, the cellular mechanisms that may explain the pro-inflammatory effect of HHcy are included. Homocysteine may directly or indirectly lead to oxidative stress or endoplasmic reticulum (ER) stress. Elevated levels of homocysteine also decrease the bioavailability of nitric oxide and modulate the levels of other metabolites including S-adenosyl methionine and S-adenosyl homocysteine which may result in cardiovascular diseases.

Key words: Homocysteine;Inflammation;cardiovascular diseases

收稿日期：　　录用日期：

通讯作者：　　E-mail:

引用本文：

戴晶, 王宪. 同型半胱氨酸在心血管疾病中的免疫调节作用[J]. 生理学报 2007; 59 (5): 585-592.

Dai Jing, Wang Xian. Immunoregulatory effects of homocysteine on cardiovascular diseases. Acta Physiol Sin 2007; 59 (5): 585-592 (in Chinese with English abstract).