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CD147相互作用蛋白及其细胞生物学功能

蒋建利, 唐娟

第四军医大学细胞工程研究中心,细胞生物学教研室,肿瘤生物学国家重点实验室.陕西,西安 710032

摘要

CD147（basigin、EMMPRIN、neurothelin、M6、HAb18G等）是一个跨膜糖蛋白家族，广泛表达于各种上皮细胞，但其表达在大鼠、小鼠、鸡和人等不同种属间存在很大差异性。CD147高表达于上皮来源的肿瘤细胞表面，如肺癌、乳腺癌和肝癌等。CD147抗原胞外段有2个IgSF结构域，跨膜区有一个带电谷氨酸（Glu）残基，胞内段含有40个氨基酸。CD147的结构特点提示其可能参与蛋白-蛋白相互作用。由于CD147分子的3D结构信息还没有获得，与其相互作用的分子还没有完全明确，但近来应用黏附、免疫共沉淀等实验方法，一些研究报道提示，CD147可与整合素（integrin）、环亲合素（cyclophilins）、单羧酸转运器（monocarboxylate transporter，MCT）等蛋白相互作用，而这些蛋白可能作为CD147分子的候选配体或受体，通过蛋白--蛋白相互作用，介导广泛的上皮细胞生物学功能。

关键词： CD147; EMMPRIN; HAb18G; 整合素; 单羧酸转运器; 环亲合素; 小窝蛋白-1; #beta#ig-h3

CD147 and its interacting proteins in cellular functions

Jiang Jianli, Tang Juan

Cell Engineering Research Centre and Department of Cell Biology, State Key Laboratory of Cancer Biology, the Fourth Military Medical University.Xi'an 710032,Shaanxi

Abstract

CD 147 （basigin, EMMPRIN, neurothelin, M6, HAb18G, etc.）, a transmembrane glycoprotein, has a broad expression pattern on various epithelial cells with some differences between species, e.g. rat, mouse, chicken and human, but is highly enriched on the surface of cancer cells of epithelial origin such as lung cancer, breast cancer and hepatoma cells. The CD147 antigen consists of two IgSF domains, a transmembrane sequence containing a charged residue （Glu） and a cytoplasmic domain of 40 residues. The particular structural features suggest that it is involved in protein-protein interactions. Although the interacting molecules are still not well known due to unavailability of the 3D structure of CD147, adhesion, coimmunoprecipitation and other studies recently suggest that several proteins, including integrins, cyclophilins, MCT, etc., interact with CD147 as its ligand or receptor candidates to mediate a wide range of cellular functions.

Key words: CD147;EMMPRIN;HAb18G;integrin;monocarboxylic acid transporter;cyclophilin;caveolin-1;#beta#ig-h3

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引用本文：

蒋建利, 唐娟. CD147相互作用蛋白及其细胞生物学功能[J]. 生理学报 2007; 59 (4): 517-523.

Jiang Jianli, Tang Juan. CD147 and its interacting proteins in cellular functions. Acta Physiol Sin 2007; 59 (4): 517-523 (in Chinese with English abstract).