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上皮细胞离子通道对雌性生殖道内液体微环境的调节作用：对生殖与不孕的影响

陈小章, 何琼, Ajonuma L C, 王晓飞

香港中文大学医学院生理学系上皮细胞生物学研究中心.香港；中国海洋大学海洋生命科学学院.山东,青岛 266003

摘要

雌性生殖道内适宜的液体微环境对一系列生殖事件起至关重要的作用。位于生殖道上皮细胞顶膜或基底膜的一系列离子通道和转运体，通过对水、电解质的跨膜转运，从而调节雌性生殖道内液体的分泌与吸收。该综述着重探讨了上皮细胞钠离子通道和囊性纤维化跨膜电导调节体对雌性生殖道内液体容量和成分的调节以及它们在不同生殖事件，比如精子获能及着床中的重要作用。同时对因离子通道失活或失调引起的雌性生殖道内液体微环境稳态失衡导致的一系列病理改变，如卵巢过度刺激综合征、输卵管积水以及不孕提出了新的见解。

关键词： 囊性纤维化跨膜电导调节体; 上皮细胞钠离子通道; 上皮细胞; 精子获能; 着床; 感染

Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment： implications in fertility and infertility

Chen Xiaozhang, He Qiong, Ajonuma L C, Wang Xiaofei

Epithelial Cell Biology Research Center, Department of Physiology, Faculty of Medicine, The Chinese University of Hong Kong.Hong Kong；China

Abstract

An optimal fluid microenvironment in the female reproductive tract is considered to be crucial for successtul reproducuve events. Fluid absorption and secretion across the reproductive tract epithelia largely depends on electrolyte transport through the apically and basolaterally located ion channels, working together with an array of other transporters. This review will discuss the role of epithelial sodium channel （ENaC） and the cystic fibrosis transmembrane conductance regulator （CFTR） in regulating the fluid volume and composition of the reproductive tract and their importance in various reproductive events such as sperm capacitation and implantation. Disturbance of the fluid microenvironment due to defects or abnormal regulation of these ion channels as causes for a number of pathological conditions, such as ovarian hyperstimulation syndromes, hydrosalpinx and infertility, is also discussed.

Key words: cystic fibrosis transmembrane conductance regulator;epithelial sodium channel;Epithelial cells;sperm capacitation;Implantation;infection

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引用本文：

陈小章, 何琼, Ajonuma L C, 王晓飞. 上皮细胞离子通道对雌性生殖道内液体微环境的调节作用：对生殖与不孕的影响[J]. 生理学报 2007; 59 (4): 495-504.

Chen Xiaozhang, He Qiong, Ajonuma L C, Wang Xiaofei. Epithelial ion channels in the regulation of female reproductive tract fluid microenvironment： implications in fertility and infertility. Acta Physiol Sin 2007; 59 (4): 495-504 (in Chinese with English abstract).