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胞外ATP在男性生殖道中的作用

周文良, 左武麟, 阮晔纯, 王喆, 杜建阳, 熊原, 陈小章

中山大学生命科学学院生理学教研室.广东,广州 510275；香港中文大学医学院生理学系上皮细胞生物学研究中心.香港

摘要

胞外ATP除了能广泛作为神经递质外，还被认为是一种旁分泌或自分泌因子。ATP从男性生殖道中的精子或上皮细胞中释放，在调节各种生殖生理功能中起多种作用。该文综述了ATP调节附睾上皮细胞阴离子分泌的信号通路，阐述了ATP对依赖上皮细胞的输精管平滑肌收缩的调节机制，讨论了ATP在男性生殖道中的功能和作用。

关键词： ATP; 附睾; 输精管; 上皮分泌; 平滑肌收缩

The role of extracellular ATP in the male reproductive tract

Zhou Wenliang, Zuo Wulin, Ruan Yechun, Wang Zhe, Du Jianyang, Xiong Yuan, Chen Xiaozhang

Department of Physiology, School of Life Science, Sun Yat-Sen University.Guangzhou 510275,Guangdong；China

Abstract

In addition to its well established role as a neurotransmitter, extracellular ATP has been considered as a paracrine/autocrine factor, either released from sperm or epithelial cells, in the male reproductive tract and shown to play a versatile role in modulating various reproductive functions. This review summarizes the signal pathways through which ATP induces anion secretion by the epithelia of the epididymis, as well as its epithelium-dependent modulation of smooth muscle contraction of the vas deferens. Finally, the overall role of ATP in coordinating various reproductive events in the male genital tract is discussed.

Key words: ATP;epididymis;vas deferens;epithelial secretion;smooth muscle contraction

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引用本文：

周文良, 左武麟, 阮晔纯, 王喆, 杜建阳, 熊原, 陈小章. 胞外ATP在男性生殖道中的作用[J]. 生理学报 2007; 59 (4): 487-494.

Zhou Wenliang, Zuo Wulin, Ruan Yechun, Wang Zhe, Du Jianyang, Xiong Yuan, Chen Xiaozhang. The role of extracellular ATP in the male reproductive tract. Acta Physiol Sin 2007; 59 (4): 487-494 (in Chinese with English abstract).