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脂肪细胞对胰岛#beta#细胞功能的内分泌调节作用

赵玉峰, 陈晨

亨利王子医学研究所内分泌细胞生物学研究室,墨尔本,维多利亚州3168

摘要

脂肪因子包括脂肪细胞分泌的多种活性因子，它们通过内分泌方式调节胰岛#beta#细胞的胰岛素分泌、基因表达以及细胞凋亡等多方面的功能。该文提出脂肪因子影响胰岛#beta#细胞功能主要通过三条相互联系的途径而实现。第一是调节#beta#细胞内葡萄糖和脂肪的代谢；第二是影响#beta#细胞离子通道的活性；第三是改变#beta#细胞本身的胰岛素敏感性。脂肪细胞的内分泌功能是一个动态过程，在不同的代谢状态下，各脂肪因子的分泌发生不同变化。从正常代谢状态发展到肥胖以及2型糖尿病的过程中，脂肪因子参与了胰岛#beta#细胞功能障碍的发生与发展。

关键词： 脂肪因子; 胰岛素; #beta#细胞; 糖尿病

Regulation of pancreatic #beta#--cell function by adipocytes

Zhao Yufeng, Chen Chen

Endocrine Cell Biology, Prince Henry's Institute of Medical Research, Melbourne, VIC 3168

Abstract

Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic #beta#-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence #beta#-cell function through three inter-dependent pathways. The first is through regulating lipid and glucose metabolism in #beta#-cells. The second implicates the change of ion channel opening and closing in #beta#-cells. The third pathway is via the modification of insulin sensitivity of #beta#-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of #beta#-cell dysfunction in type 2 diabetes.

Key words: adipokines;Insulin;#beta#-cells;Diabetes

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引用本文：

赵玉峰, 陈晨. 脂肪细胞对胰岛#beta#细胞功能的内分泌调节作用[J]. 生理学报 2007; 59 (3): 247-252.

Zhao Yufeng, Chen Chen. Regulation of pancreatic #beta#--cell function by adipocytes. Acta Physiol Sin 2007; 59 (3): 247-252 (in Chinese with English abstract).