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硫化氢与细胞的增殖和凋亡

杨广东, 王睿

Lakehead大学医学研究中心,雷湾,安大略,P7B 5E1

摘要

硫化氢是内源性气体分子家族中的一员，是一种气体递质(gasotransmitter)。近年来，内源性硫化氢的产生及生理意义已经被认识，其代谢异常与许多疾病有关。该文综述了最近发现的硫化氢对细胞增殖和凋亡的调节作用，并重点概述硫化氢细胞效应的分子机制，包括丝裂原活化蛋白激酶、细胞周期相关激酶、细胞死亡相关基因以及离子通道等的改变。对硫化氢调节细胞生长或死亡的深入了解将为新药设计及许多疾病的治疗提供新的思路。

关键词： 硫化氢; 气体递质; 胱硫醚#gamma#-裂解酶; 增殖; 凋亡

H_(2)S and cellular proliferation and apoptosis

Yang Guangdong, Wang Rui

Medical Research Centre, Lakehead University, Ontario P7B 5E1

Abstract

Hydrogen sulfide (H_(2)S) is among a family of endogenous molecules of gas, defined as gasotransmitters. In recent years,endogenous production of H_(2)S and its physiological importance have been realized. Abnormal metabolism and functions of H_(2)S contribute to or participate in the pathogenesis of many diseases. This article reviews recent discoveries on the roles of H_(2)S in the regulation of cell proliferation and apoptosis. The molecular mechanisms for the cellular effects of H_(2)S are also recapitulated, including changes in mitogen-activated protein kinase, cell cycle-related kinase, cell death-related gene and ion channels. A better understanding of H_(2)S-regualted cell growth or death will pave way for future design of novel pharmacological and therapeutic interventions for various diseases.

Key words: H_(2)S;gasotransmitter;cystathionine #gamma#-lyase;Proliferation;Apoptosis

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引用本文：

杨广东, 王睿. 硫化氢与细胞的增殖和凋亡[J]. 生理学报 2007; 59 (2): 133-140.

Yang Guangdong, Wang Rui. H_(2)S and cellular proliferation and apoptosis. Acta Physiol Sin 2007; 59 (2): 133-140 (in Chinese with English abstract).