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迷走神经对心室功能的调控机制研究进展

臧伟进, 陈莉娜, 于晓江

西安交通大学医学院药理学系心血管生理药理研究室. 陕西，西安 710061

摘要

自主神经系统由交感神经系统和副交感神经系统(迷走神经)组成，二者相互拮抗，对哺乳动物心脏的功能调控具有重要的作用。副交感(迷走)神经对心房可产生变时、变传导和变力作用，但是对心室的支配及对心室的调控作用还不清楚。一直以来都存在一个误解，认为交感神经支配心脏的各个部位而副交感神经仅支配心脏的室上性组织，对心室没有支配。近年来的研究显示在一些哺乳动物的心脏上，胆碱能神经在心室也有分布，且对左心室的功能有重要的调控作用。该文从解剖及组织化学、分子生物学和功能学三个方面阐述迷走神经对心室的支配及调控证据，并对心室收缩功能的迷走神经(毒蕈碱)调控及其信号转导途径进行综述。

关键词： 迷走神经; 毒蕈碱受体; 心室; 变力作用; 信号转导

Progress in the study of vagal control of cardiac ventricles

Zang Weijin, Chen Lina, Yu Xiaojiang

Division of Cardiovascular Physiology and Pharmacology, Department of Pharmacology, School of Medicine, Xi'an Jiaotong University.Xi'an 710061,Shaanxi

Abstract

Autonomic nervous system plays an important role in the regulation of mammalian heart, and it is divided into the sympathetic and parasympathetic (vagal) subsystems. The parasympathetic (vagal) control of the atria involves modulation of chronotropic, dromotropic and inotropic activities, but the role of the parasympathetic innervation of the ventricles is still unclear. There is a common misconception that the sympathetic nerves innervate all over the heart; while the parasympathetic nerves only innervate the superventricular part of the heart, but not the ventricles. Recent evidence indicates that the cholinergic innervation of the left ventricle is functionally very important in some mammalian species. The present article reviews the evidence of vagal control in the ventricles from the anatomy and histochemistry, molecular biology, and function areas. Additionally we overview the vagal (muscarinic) regulation of cardiac contractile function and its signal transduction.

Key words: Vagus nerves;muscarinic receptor;ventricle;Inotropism;Signal transduction

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引用本文：

臧伟进, 陈莉娜, 于晓江. 迷走神经对心室功能的调控机制研究进展[J]. 生理学报 2005; 57 (6): .

Zang Weijin, Chen Lina, Yu Xiaojiang. Progress in the study of vagal control of cardiac ventricles. Acta Physiol Sin 2005; 57 (6): (in Chinese with English abstract).