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转录因子Egr-1参与长期性恐惧记忆和焦虑

Shanelle W. Ko, 敖虎山, Amelia Gallitano-Mendel, 邱长申, 魏峰, Jeffrey Milbrandt, 卓敏

多伦多大学医学院生理系，多伦多大学痛觉研究中心，多伦多，安大略省 M5S1A8，加拿大；华盛顿大学医学院病理和精神病系，圣路易丝，密苏里州 63110，美国

摘要

锌指转录因子Egr-1在将细胞外信号和胞内基因表达的变化相耦联过程中发挥重要的作用。海马和杏仁体是记忆形成 和储存的两个主要的脑区。在海马和杏仁体中，Egr-1 可被长时程增强(long-term potentiation, LTP)和学习过程上调。在Egr-1敲除小鼠上观察到晚时相声音恐惧记忆受损，而短时的痕迹和场景记忆却不受影响；另外，在 Egr-1敲除小鼠上，用theta burst刺激杏仁体和听觉皮层所引起的突触增强被明显减弱或完全阻断。因此，我们的研究表明，转录因子 Egr-1选择性地在晚时相听觉恐惧记忆中发挥作用。

关键词： Egr-1; 长时程增强; 恐惧记忆; 杏仁体; 听觉皮层

Transcription factor Egr-1 is required for long-term fear memory and anxiety

Shanelle W. Ko, Ao Hushan, Amelia Gallitanomendel, Qiu Changshen, Wei Feng, Jeffrey Milbrandt, Zhuo Min

Department of Physiology, University of Toronto, Faculty of Medicine, University of Toronto Centre for the Study of Pain, Medical Science Building, King's College Circle, Toronto, Ontario, M5S 1A8, Canada

Abstract

The zinc finger transcription factor Egr-1 is critical for coupling extracellular signals to changes in cellular gene expression. In the hippocampus and amygdala, two major central regions for memory formation and storage, Egr-1 is up-regulated by long-term potentiation (LTP) and learning paradigms. Using Egr-1 knockout mice, we showed that Egr-1 was selectively required for late auditory fear memory while short term, trace and contextual memory were not affected. Additionally, synaptic potentiation induced by theta burst stimulation in the amygdala and auditory cortex was significantly reduced or blocked in Egr-1 knockout mice. Our study suggests that the transcription factor Egr-1 plays a selective role in late auditory fear memory.

Key words: Egr-1;Long-term potentiation;Fear memory;;

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引用本文：

Shanelle W. Ko, 敖虎山, Amelia Gallitano-Mendel, 邱长申, 魏峰, Jeffrey Milbrandt, 卓敏. 转录因子Egr-1参与长期性恐惧记忆和焦虑[J]. 生理学报 2005; 57 (4): .

Shanelle W. Ko, Ao Hushan, Amelia Gallitanomendel, Qiu Changshen, Wei Feng, Jeffrey Milbrandt, Zhuo Min. Transcription factor Egr-1 is required for long-term fear memory and anxiety. Acta Physiol Sin 2005; 57 (4): (in Chinese with English abstract).