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中枢白细胞介素-1在应激反应中的作用

郑瑞茂, 祝世功

北京大学基础医学院生理学与病理生理学系. 北京 100083；中国科学院心理研究所脑高级功能实验室，脑与认知科学 国家重点实验室. 北京 100101

摘要

白细胞介素-1(interleukin-1, IL-1)系统分子广泛分布于中枢神经系统。中枢IL-1具有极其丰富的生物学功能，作为经典炎性细胞因子，在多种生理、病理生理过程中起重要作用。近几年来，中枢IL-1的应激介质作用备受关注。本文综述了中枢IL-1在应激反应中作用的最新进展，包括应激对中枢IL-1系统的影响，中枢IL-1对应激反应的启动和介导作用；参与中枢IL-1应激介导作用的神经环路和细胞信号转导通路，以及中枢IL-1对应激时脑高级功能和行为反应的影响。

关键词： Interleukin-1; Central nervous system; Stress

Role of the central interleukin-1 in stress responses

Zheng Ruimao, Zhu Shigong

Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University. Beijing 100083, China；2Laboratory for Higher Brain Functions, State Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences. Beijing 100101, China

Abstract

The molecules of interleukin-1 (IL-1) system are widely distributed in central nervous system. As a classical pro-inflammatory factor, central IL-1 has diverse biological functions and plays a pivotal role in a number of important physiological and pathophysiological processes. During the past few years, particular attentions have been directed to the stress mediator actions of central IL-1. This paper reviews some recent findings in the studies of central IL-1 functions in stress responses, including the effects of stress on central IL-1, the roles of IL-1 in the initiation of stress responses, the neural circuitries and intracellular signal transduction pathways involved in the central IL-1 mediated stress responses, as well as the actions of central IL-1 on brain high function and behavior under stressful conditions.

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引用本文：

郑瑞茂, 祝世功. 中枢白细胞介素-1在应激反应中的作用 [J]. 生理学报 2005; 57 (4): .

Zheng Ruimao, Zhu Shigong. Role of the central interleukin-1 in stress responses. Acta Physiol Sin 2005; 57 (4): (in Chinese with English abstract).