ISSN 0371-0874, CN 31-1352/Q

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月经周期对女性睡眠-觉醒和静息-活动的影响

刘红艳, 包爱民, 周江宁, 刘荣玉

安徽医科大学第一附属医院老年呼吸内科. 安徽, 合肥 230022;中国科学技术大学生命科学院神经生物学系. 安徽, 合肥 230027

摘要

目前有关月经周期对睡眠影响的研究结果并不一致,而对月经周期中昼夜睡眠-觉醒及静息-活动节律尚缺乏系统性的研究。该研究旨在观察正常育龄期女性月经周期中睡眠-觉醒及静息-活动昼夜节律的变化.我们采用静息-活动监测仪(actigraphy)和睡眠日志,调查了12个自然生活状态下健康育龄期妇女在月经周期不同阶段,即行经期、围排卵期、黄体早期及黄体晚期中睡眠与活动节律的变化.结果显示,睡眠-觉醒节律参数在四期之间无统计学显著差异;而静息-活动节律方面,所有受试女性静息-活动节律的平均日周期长度为(24.01±0.29)h,并且四期之间无显著性差异.行经期日间稳定系数(interdaily stability,IS)比黄体早期显著增加(P<0.05).黄体早期日间活动开始时间明显较黄体晚期提前(P<0.05);黄体早期的活动峰值时相比围排卵期显著提前(P<0.05).月经周期可以影响静息-活动昼夜节律时相.而总体静息-活动数量与质量未发生显著变化;健康育龄期妇女在月经周期的各阶段中睡眠-觉醒节律亦无明显变异。

关键词: 昼夜节律; 月经周期; 静息-活动; 睡眠; 监测仪

Changes in circadian sleep-wake and rest-activity rhythms during different phases of menstrual cycle

Liu Hongyan, Bao Aimin, Zhou Jiangning, Liu Rongyu

Lung Department of Geriatrics Institute, The First Affiliated Hospital of Anhui Medical University. Hefei 230022, Anhui, China

Abstract

The results of previous studies on the menstrual-related sleep changes were inconsistent. The menstrual-related circadian sleep-wake and rest-activity rhythms changes are still uncertain. Using actigraphic monitoring of wrist activity, we investigated the sleep-wake and rest-activity patterns of 12 normally cyclic healthy women during reproductive life. Multivariate analyses were performed during the four phases of the menstrual cycle: menstrual phase (lst to 5th day of menstrual cycle), late follicular/peri-ovulation phase (11 th to15th day), early to mid luteal phase (18th to 23th day) and late luteal phase (25th to 28th day), respectively. The variables of circadian sleep-wake pattern were similar in the four phases, except an increased tendency of the sleep latency in peri-ovulation phase compared with the early to mid-luteal phase (19±18 vs 9±6), but unfortunately no statistical significance were found (P<0.10). Concerning the circadian patterning of rest and activity, the interdaily stability (IS) in menstrual phase was significantly higher than the early to mid luteal phase (P<0.05). In early to mid luteal phase, the M10 onset time was significantly earlier compared with that of the late follicular/peri-ovulation phase (P<0.05), and the cosinor peak time was significantly earlier compared with that of the late luteal phase (P<0.05). The circadian periodogram calculated the period length of the rhythm of average woman. The average length was (24.01±0.29) h, and there was no significant difference among the four menstrual phases. The results suggest that the phase of circadian rest-activity rhythm may be modulated by the menstrual cycle, but the quantity and quality of the rest-activity rhythm have no essential different, and that menstrual cycle may have no effects on the circadian sleep-wake rhythm in normally cyclic healthy women.

Key words: Circadian rhythm;Menstrual cycle;Rest-activity;Sleep;Actigraphy

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引用本文:

刘红艳, 包爱民, 周江宁, 刘荣玉. 月经周期对女性睡眠-觉醒和静息-活动的影响[J]. 生理学报 2005; 57 (3): .

Liu Hongyan, Bao Aimin, Zhou Jiangning, Liu Rongyu. Changes in circadian sleep-wake and rest-activity rhythms during different phases of menstrual cycle. Acta Physiol Sin 2005; 57 (3): (in Chinese with English abstract).