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家兔单侧、双侧Botzinger复合体内微量注射甘氨酸及士的宁对膈神经放电的影响

吕明, 李勤, 宋刚, 张衡, 刘磊

聊城市人民医院神经外科. 山东, 聊城 252000；山东医科大学基础医学院生理学教研室. 济南 250012

摘要

微量注射抑制性神经递质甘氨酸及其受体阻断剂士的宁，观察膈神经放电的变化。结果如下：（1）单侧注射甘氨酸使呼吸频率增加，呼气相膈神经出现放电活动；（2）双侧Bot．C注射甘氨酸后呼气相消失，膈神经呈无节律紧张性放电，幅度为前对照吸气放电幅度的40％~70％。士的宁能竞争性阻断甘氨酸的效应；（3）双侧Bot．C注射士的宁后，呼吸频率减慢，呼气时程延长，膈神经放电幅度降低，吸气时程无明显变化。

关键词： Botzubger复合体; 膈神经放电; 微量注射; 甘氨酸; 士的宁

Abstract

The effects of microinjection of glycine and strychnine into unilateral and bilateral and bilateral Botzinger complex (bot . C) on phrenic nerve discharges were observed in 34 urethane anaesthetized,vagotomized, paralyzed and artificially rabbits,The results are as follows: (1) microinjection of glycine into unilateral Bot. C induced an increase of respiratory rate and expiratory ptrenic nerve discharges;(2) microinjection of glycine into bilateral Bot.C induced non-rhythmic tonic phrenic nerve discharges with an amplitude 40% ~ 70% of control; strychnine could competitively antagonize the effects of glycine; and (3) microinjection of strychnine into bilateral Bot. C induced a decrease of respiratory rate and the amplitude of phrenic nerve discharges , in addition to prolongation of expiratory duration while inspiratory duration remained unchanged. The above results suggest that the Bot. C plays a crucial role in initiating and sustaining expiration.

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引用本文：

吕明, 李勤, 宋刚, 张衡, 刘磊. 家兔单侧、双侧Botzinger复合体内微量注射甘氨酸及士的宁对膈神经放电的影响[J]. 生理学报 1998; 50 (6): .

, , , , . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).