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基底外侧杏仁核对睡眠-觉醒的调节作用

朱国庆, 钟明奎, 张景行, 赵乐章, 柯道平, 王敏, 施蕾

安徽医科大学生理教研室. 合肥 230032；安徽中医学院生理教研室. 合肥

摘要

采用多道睡眠描记方法，观察了基底外侧杏仁核（BLN）在睡眠-觉醒调节中的作用。结果发现，电损毁双侧BLN引起慢波睡眠（SWS）和快波睡眠（PS）增加，觉醒（W）减少；在双侧BLN内注射选择性损毁神经元胞体剂量的红藻氨酸（KA）引起双相效应，注射KA后第1天出现失眠，自第3天开始，SWS增多，W减少，但PS无显著变化。一侧BLN内注射一氧化氮（NO）供体硝普钠可使W增加，SWS减少，而一氧化氮合酶（NOS）抑制剂L-硝基精氨酸（L-NNA）则引起SWS增多，W减少和睡眠加深；NO前体L-精氨酸（L-arg）对睡眠无直接影响，但可完全对抗L-NNA的促睡眠效应。

关键词： 杏仁核; 红藻氨酸; 一氧化氮; 睡眠; 觉醒

Abstract

he role of basolateral amygdaloid nuclei (BLN) in sleep and wakeful state (W)was investigated with polysomnography. Electrical lesion of bilatend BLN increased slow wave sleep (SWS) and paradoxical sleep (PS), but decreased W. Bilateral injection of kainic acid (KA), which selectively destroyed the soma of neurons, resulted in biphasic effects-At d 1 after KA, insmmia occurred. At d 4, SWS increased while W decreased,but PS did not change. Unilateral injection of NO donor sodium nitroferricyanide (SNP)caused an enhanement of W and a decrease of SWS. Injection of nitric oxide synthase inhibitor N-nitro-L-arginine (L-NNA) led to opposite effects. L-arginine, a precursor of NO, had no direct effect on sleep and W, but blocked the effects of L-NNA.The results suggest.-that BLN plays an important rofe in regulating sleep and wakeful state.Destruction of BLN increases SWS, and NO in BLN has W-prornoting and SWS-inhibiting effects, which may be mediated by activation of neurons in BLN.

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引用本文：

朱国庆, 钟明奎, 张景行, 赵乐章, 柯道平, 王敏, 施蕾. 基底外侧杏仁核对睡眠-觉醒的调节作用[J]. 生理学报 1998; 50 (6): .

, , , , , , . . Acta Physiol Sin 1998; 50 (6): (in Chinese with English abstract).