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NMDA和非NMDA受体拮抗剂对伤害性辐射热引起的缩腿反射抑制的比较

舒友生, 赵志奇

中国科学院上海脑研究所

摘要

我们以前的电生理工作表明：N-甲基-D-门冬氨酸（N－methyl－D－aspwhcacid，NMDA）受体主要参与介导皮肤来源的伤害性信息的传入，而非NMDA受体主要参与介导肌肉来源的伤害性信息的传入。为进一步证实这一发现，应用鞘内注射（intrathecalinjection，it）的方法，观察NMDA和非NMDA受体拈抗剂对大鼠伤害性辐射热刺激所引起的缩腿反射潜伏期（pawwithdrawallatency，PWL）的影响。鞘内注射1nmol／L非NMDA受体措抗剂DNQX（6，7－dinitroquinoxaline-2，3（1H，4H）-dione）对PWL没有作用，但1nmol／LNMDA受体拮抗剂APV[（±）2－amino-5－phosphonovalerate]显著延长PWL（P＜0．05）。10nmol／LDNQX和10nmol／LAPV均显著地使PWL延长，但是10nmol／LAPV增加PWL的百分比显著大于10nmol／LDNQX增加PWL的百分比（P＜0．05）。结果提示，NMDA和非NMDA受体均参与介导脊髓的伤害性信息的传递，NMDA受体可能主要介导皮肤伤害性信息的传递。

关键词： 鞘内注射; 缩腿反射潜伏期; NMDA受体; 非NMDA受体; 皮肤痛

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

In our previous electrophysiological study, it was shown that N'MDA receptors are predodrinately involved in the transmission of nociceptive cutaneous afferents, whereas non-N'MDA receptors are mainly concerned with the transmission of nociceptive muscular afferents. In the present investigation, the effects of NMDA and non-N'MDA receptor antagonists were tested in rat hindpaw withdraWal resPOnse to noxious thermal shmulation. Ihtrathecal application of non-NMDA receptor antagonist 1 runoUL DNQX (6, 7dinimpinoxaline-2, 3 (IH, 4H)-dione ) had no effect on paw withdrawal latencies(PWL ), but NMDA receptor antagonist I runoUL APV [(l ) 2-piano-5phosphonovalerate) ] significantly prolonged Pad (P < 0.05). Both APV and DNQX at10 nmoUL significantly increased PWL with the former agent being more potent.

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引用本文：

舒友生, 赵志奇. NMDA和非NMDA受体拮抗剂对伤害性辐射热引起的缩腿反射抑制的比较 [J]. 生理学报 1998; 50 (3): .

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).