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腺苷对颈动脉窦压力感受器反射的易化作用

陈爽, 范振中, 何瑞荣

河北医科大学基础医学研究所生理室

摘要

在27只隔离灌流颈动脉窦区的麻醉大鼠，观察了腺苷（adenosine，Ado）对颈动脉窦压力感受器反射的影响。所得结果如下：（1）以Ado（125μmol／L）隔离灌流大鼠左侧颈动脉窦区时，压力感受器机能曲线向左下方移位，曲线最大斜率（PS）由0．37±0．02增至055±0．02kPa／KPa（P＜0．001），反射性血压下降幅度（RD）由5．53±0．12增至7．76±0．36KPa；阈压（TP）、平衡压（EP）和饱和压（SP）则分别从8．60±0．27，12．53±0．30和23．69±0．15下降至5．63±0．11kPa，10．89±0．29KPa和20．18±0．55KPa（P＜0．01－0．001）。其中RD，PS和TP的变化呈明显的剂量依赖性。（2）用腺苷选择性A1受体拮抗剂（8－cyclopentyl－l，3－dipropylianthene，0．134mmol／L）预处理后，Ado的上述反射效应即被阻断。（3）先给予KATP通道阻断剂格列苯脲（glibenclamide．10μmol／L）亦可取消腺苷对压力感受器反射的影响。以上结果表明，Ado对大鼠颈动脉窦压力感受器活动有易化作用，这一作用似与腺苷A1受体介导的KATP通道开放有关。

关键词： 腺苷; 颈动脉窦压力感受器反射; 平均动脉压

Cui Hong

First Clinical Institute，China Medical University. Shenyang 110001,Liaoning, China

Abstract

The effects of adenosine (Ado) on the carotid barewhex were studied in 27 anesthetized rats with isolated caretid sinus pemision. The restilts obtained were as follows: (1) By perfusing the isolated carotid sinus with adenosine (125 μmol/L), the functional curve of bamreflex was shifted to the left and downward, with the peak slope (PS) increased from 0.37±0.02 to 0.55±0.02 kPa/kPa (P<0.001) and the reflex decrease in mean alienal pressure (RD) enhanced from 5. 53±0.12 to 7 .76±0. 36 kPa (P<0.001). Meanwhile, the theshold pressure (TP), eqUilibrium pressure (EP) and saturation pressure (SP) were significantly decreased from 8. 60±0 .27 to 5. 63±0. 11 kPa (P<0.001), 12.53±0.30 to 10.89±0.29 kPa (P<0.01) and 23.69±0. 15 to 20. 18±0.55 kPa (P<0.001), respectively. Among the functional parameters of camtid hamreflex I the changes of RD,PS and TP induced by Ado were dose-dependent.

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引用本文：

陈爽, 范振中, 何瑞荣. 腺苷对颈动脉窦压力感受器反射的易化作用 [J]. 生理学报 1998; 50 (3): .

Cui Hong. . Acta Physiol Sin 1998; 50 (3): (in Chinese with English abstract).