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刺激中缝背核不同区域对颏舌肌和膈肌的影响

于萍, 宋刚, 刘磊, 刘沂训

山东医科大学基础医学院生理教研室；机能中心实验室

摘要

本实验在48只氨基甲酸乙酯麻醉、断双侧迷走神经的健康家兔上观察了电、化学刺激中缝背核背侧区（dNRD）和腹侧区（VNRD）对颏舌肌和膈肌肌电积分活动的影响。结果如下：（1）长串电脉冲刺激dNRD使额舌肌和隔肌肌电活动均明显增强；（2）长串电脉冲刺激vNRD时，颏舌肌活动被易化，而膈肌活动则被抑制；（3）在dNRD和vNRD分别微量注射谷氨酸钠，其效应与电刺激结果基本一致。结果提示：中缝背核（NRD）的兴奋可加强颏舌肌的活动，从而可能使上呼吸道阻力降低，其不同核区对呼吸有不同的调制作用。

关键词： 中缝背核; 颏舌肌; 膈肌; 上呼吸道阻力

MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

Effects of electrical and chemical stimulation of the dorsal and ventral areas of the nucleus raphe dorslis(dNRD and vNRD)on genioglossus and diaphragm activities were observed in 48 urethan-anasthetized and vagotomized raddits.(1)Long train electrical stimulation at the dNRD facilitated genioglossus and diaphragm activities.(2)Long train electrical stimulation delivered to the vNRD excited genioglOssus activity but inhibited diaphragm activity.(3)Effects of microinjection of glutamate at the dNRD and vNRD were simillar to the effects of electrical stimulation.The above results suggest that excitation of nucleus raphe dorsalis(NRD)increases genioglossus activity and reduces upper airway resistance.The dNRD and vNRD play different roles in modulating diaphragm activity.

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引用本文：

于萍, 宋刚, 刘磊, 刘沂训. 刺激中缝背核不同区域对颏舌肌和膈肌的影响 [J]. 生理学报 1998; 50 (1): .

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).