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大鼠鞘内注射多巴胺受体激动剂与拮抗剂对痛及针刺镇痛的影响

高秀, 辛冰牧, 朱崇斌, 吴根诚, 许绍芬

上海医科大学医学神经生物学国家重点实验室

摘要

在大鼠电刺激甩尾测痛模型上，应用鞘内注射（it）多巴胺（DA）受体选择性激动剂与拮抗剂，分析大鼠脊髓DA受体亚型D1和D2在痛及针刺镇痛（AA）中的作用。结果显示，在正常清醒大鼠，itD2受体选择性激动剂LY171555（LY）或D1／D2受体激动剂阿朴吗啡（APO）有镇痛作用（呈剂量依赖式增加），并加强AA，而itD1受体选择性激动剂SKF38393（SKF）对痛及AA均无影响；itD1受体选择性桔抗剂SCH23390（SCH）或D2受体选择性拮抗剂舒必利（Sul）均减弱AA的效应。结果提示，在脊髓水平，D2受体参与痛觉的调制，兴奋D2受体时有镇痛作用并增强AA；兴奋D1受体时显示不出参与作用，但阻断D1受体能抑制AA。

关键词： 多巴胺受体; 针刺镇痛; 鞘内注射; 阿朴吗啡; SKF38393; LY; 舒必利; SCH23390

MA Yong-Jie

2College of Information Engineering, Taishan Medical University, Taian 271016, China

Abstract

Some selective dopamine receptor agonists and antagonists were tested on rat tail flick model to investigate the role of D1 and D2 dopamine receptor in pain and acupuncture analgesia(AA).It was found that intrathecal administraion(it)of D2 receptor agonist LY171555 or D1/D2 receptor agonist apomorphine increased pain threshold and had a potentiating effect on AA.In contrast,D1 receptor agonist SKF38393 had no effect.It D1 receptor antagonist SCH2339O or D2 receptor antagonist sulPiride attenuated the effect of AA.The results suggest that D2 receptor is involved in pain modulation and activation of D2 receptor and enhances AA in the spinal cord,while such effect is absent in D1 receptor and inactivation of D1 receptor attenuates AA.

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引用本文：

高秀, 辛冰牧, 朱崇斌, 吴根诚, 许绍芬. 大鼠鞘内注射多巴胺受体激动剂与拮抗剂对痛及针刺镇痛的影响[J]. 生理学报 1998; 50 (1): .

MA Yong-Jie. . Acta Physiol Sin 1998; 50 (1): (in Chinese with English abstract).