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Anordrin诱发幼年大鼠子宫嗜伊红细胞增多的荧光组织化学研究

杨以谦, 吴晓云, 任惠民, 章生艮

上海市计划生育科学研究所. 上海；中国科学院上海生理研究所. 上海

摘要

该工作对Anordrin诱发幼年大鼠子宫嗜伊红细胞增多进行了研究,取得如下结果:(1)Anordrin 可诱发子宫嗜伊红细胞增多与子宫增重,两者近乎平行。(2)皮下注射远较口服的效应强。(3)注射一次Anordrin(100μg)后24h出现子宫反应,随后2-24d持续高反应,27d后渐趋下降。(4)Anordrin类似物SIPPR-113的雌激素活性较低,其诱发子宫嗜伊红细胞的效应甚微,子宫也无明显增重。

关键词： 子宫; 嗜伊红细胞; Anordrin; 雌激素活性

A fluorescence histochemical study of uterine eosinophilia induced by anororin in immature rats

Yang Yiqian, Wu Xiaoyun, Ren Hueimin, Zhang Shenggen

Shanghai Institute of Planned Parenthood Research；Shanghai Institute of Physiology, Academia Sinica

Abstract

A fluorescence histochemical demonstration of uterine cositophilia induced by the Anordrin was studied in immature Wistar rats with the following results:
(1) Anordrin induced uterine eosinophilia and a nearly parallel increase in weight. (2) Subcutaneous injection showed much more potent effects than oral administration. (3) After a single injection of Anordrin (100ikg), the induced uterine effects could be noticed in about 24h and thereafter maintained at a high level during the subsequent 2-24 d period which then gradually subsided after 27th day.(4) SIPPR-113, an Anordrin analogue, with lower estrogenicity induced little migration of eosinophils into the uterus and slight increase in uterine weight.

Key words: Uterus;Eosinophil;Anordrin;Estrogenic activity

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引用本文：

杨以谦, 吴晓云, 任惠民, 章生艮. Anordrin诱发幼年大鼠子宫嗜伊红细胞增多的荧光组织化学研究[J]. 生理学报 1987; 39 (5): .

Yang Yiqian, Wu Xiaoyun, Ren Hueimin, Zhang Shenggen. A fluorescence histochemical study of uterine eosinophilia induced by anororin in immature rats. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).