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猫丘脑束旁核神经元对电刺激外周神经与动脉注射缓激肽的放电反应

杨焕乔, 杨振荃

上海职工医学院. 上海；中国科学院上海脑研究所. 上海

摘要

为了确定丘脑束旁核神经元对外周神经伤害性刺激的各类反应是否都属于痛敏反应,在氯醛糖麻醉的36只猫上观察了束旁核神经元对强电流刺激外周神经与动脉注射缓激肽的放电反应。根据放电的潜伏期和持续时间,可将观察到的162个单位对强电流刺激外周神经的反应分成四种类型。1.短潜伏期反应,69个单位。2.长潜伏期反应,15个单位。3.短-长潜伏期反应,37个单位。4.自发放电抑制,41个单位。静脉注射芬太尼不能抑制短潜伏期反应,动脉注射缓激肽不能诱发这类神经元放电,说明这类反应不是痛敏反应。

关键词： 束旁核神经元; 外周神经; 缓激肽; 伤害性放电反应

Response of neurons in cat parafascicular nucleus of thalamus to noxious stimulation of peripheral nerves and intra-arterial injection of bradykinin

Yang Huanqiao, Yang Zhenquan

Shanghai Medical College for staff；Shanghai Brain Research Institute, Academia Sinica

Abstract

Responses of neurons in parafascicular nucleus of thalamus (Pf) to noxious
stimulation of cutaneous (sural) nerve and deep (gastrocnemius) nerve as well as
to injection of Bradykinin (BK) into gastrocnemius artery were studied in 36 cats anesthetized with chloralose.162 units were studied, among which 143 units (88.3%)were found to respond to both sural and gastrocnemius nerve stimulation, while the other 19 units (11.7%)l only to gastrocnemius stimulation. According to the pattern of discharges and latencies of the responses, Pf neurons could be classified into 4 types: (1) 69 units.responded to nerve stimulation with short latlency(usually 20-40 ms) discharges. Administration of Fentanyl (30#mu#g/kg, i.v.) did not affect the responses and BK (20#mu#g/kg, i. v.) did not evoke discharges in all 7 units tested. (2) 15 units had latencies longer than 100 ms. (3) The responses of 37 units started with an early short burst of discharges followed by a late long and lasting firing with long latency.(4) The spontaneous discharges of 41 units were inhibited by stimulation of the peripheral nerves. Fentanyl (30u#mu#/kg, i.v.) remarkably suppressed the long latency discharges of type 3 neurons and abolished the inhibitory responses of the spontaneous discharges of type 4 neurons evoked by noxious stimulation. BK
(20#mu#g/kg, i.a.) could excite both type 2 and 3 neurons and inhibited the
spontaneous discharges of type 4 neurons. It is concluded that all types of the Pf neurons, except type 1, might be regarded as nociceptive, in which either excitatory or inhibitory responses could be produced by noxious stimulation.

Key words: Parafascicular neuron;Peripheral nerve;Bradyldnin;Nociceptive discharges

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引用本文：

杨焕乔, 杨振荃. 猫丘脑束旁核神经元对电刺激外周神经与动脉注射缓激肽的放电反应[J]. 生理学报 1987; 39 (5): .

Yang Huanqiao, Yang Zhenquan. Response of neurons in cat parafascicular nucleus of thalamus to noxious stimulation of peripheral nerves and intra-arterial injection of bradykinin. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).