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山莨菪碱抑制内毒素诱导血小板聚集作用

朱广瑾, 许澍淮, 薛全福, 陈华粹

中国医学科学院基础医学研究所

摘要

大肠杆菌内毒素诱导兔体内、外血小板聚集,使血小板内cAMP水平降低。山莨菪碱能抑制内毒素诱导的血小板聚集,并提高血小板内cAMP的水平。山莨菪碱提高血小板内cAMP 的作用可为β-受体阻断剂心得舒阻断。

关键词： 大肠杆菌内毒素; 山茛菪碱(又名654); 心得舒; 环磷酸腺苷(cAMP); 循环血小板聚集率

The mechanism of inhibition of anisodamine on platelet aggregation induced by e. Coli endotoxin

Zhu Guangjin, Xu Shuhuai, Xue Quanfu, Chen Huacui

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences

Abstract

The platelet aggregation induced by E. coli endotoxin both in vivo and in vitro in rabbit were observed. The platelet level of cAMP was decreased by intervention of E. coli endotoxin in vitro. Anisodamine inhibited the platelet aggregation induced by E. coli endotoxin and increased the level of CAMP. This effect increased cAMP level could be blocked by alprenolol (a #beta#-receptor blockade).

Key words: E. coli endotoxin;Anisodamine;Alprenolol;Cyclic-AMP;PACR

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引用本文：

朱广瑾, 许澍淮, 薛全福, 陈华粹. 山莨菪碱抑制内毒素诱导血小板聚集作用[J]. 生理学报 1986; 38 (3): .

Zhu Guangjin, Xu Shuhuai, Xue Quanfu, Chen Huacui. The mechanism of inhibition of anisodamine on platelet aggregation induced by e. Coli endotoxin. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).