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家兔油酸型急性呼吸窘迫综合征时肺动脉血压的变化

倪慧, 张尚俭, 张日新, 沈上, 严传华

南京医学院生理教研室. 江苏；新疆石河子医学院生理教研室. 新疆；南京卫生学校生理教研组. 江苏

摘要

该文介绍家兔油酸型呼吸窘迫综合征时肺动脉血压的变化。静脉注入油酸后,肺血管阻力显著增加,股动脉血压、心率和心输出量均下降;肺动脉压则升高,并经历最初快速升高、相对稳定和后期升高三个时相变化。预先注射神经节阻滞剂六甲双胺或α-受体阻断剂酚妥拉明,然后注射油酸,肺动脉压的最初快速升高期不出现。切断两侧颈动脉窦神经或两侧颈部迷走神经对其并无影响。此外,在后期,六甲双胺及酚妥拉明两者均不能阻断肺动脉压的上升。上述结果表明,动物注射油酸后,肺动脉压的最初快速升高是通过交感神经实现的。肺动脉压的后期升高则是缺氧或其他因素所造成。

关键词： 急性呼吸窘迫综合征; 油酸; 肺动脉压; 肺血管阻力; 六甲双胺; 酚妥拉明

Changes in pulmonary arterial pressure during acute respiratory distress syndrome caused by injection of oleic acid in rabbits

Ni Hui, Zhang Shangjian, Zhang Rixin, Shen Shang, Yan Chuanhua

Department of Physiology, Nanjing Medical College. Nanjing, Jiangsu, China

Abstract

This paper reports the changes in pulmonary arterial pressure during the acute respiratory distress syndrome caused by oleic acid injection in rabbits. Following intravenous injection of oleic acid the pulmonary vascular resistance was found to be increased markedly while the arterial pressure, heart rate and the cardiac output were lowered. The pulmonary arterial pressure was increased accordingly which showed phasic alterations, i.e., initial rapid rise, relative stable period and a subsequent late increase. Pretreatment with ganglionic blocking agent-hexamethonium as well as“blocker- phentolamine abolished the initial rapid rise of pulmonary arterial pressure following injection of oleic acid. Bilateral severance of sinus nerves or cervical vagus nerves had no effect. Moreover, neither hexamethonium nor phentolamine could block the rise of pulmonary arterial pressure in the late stage. It is thus assumed that the initial rapid rise of pulmonary arterial pressure following injection of oleic acid involves the activities of sympathetic nerves, while its late increase is mainly due to the ensuing anoxia and the relevant factors involved.

Key words: Acute respiratory distress syndrome;Oleic acid;Pulmonary arterial pressure;Pulmonary vascular resistance;Hesamethonium;Phentolamine

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引用本文：

倪慧, 张尚俭, 张日新, 沈上, 严传华. 家兔油酸型急性呼吸窘迫综合征时肺动脉血压的变化[J]. 生理学报 1986; 38 (3): .

Ni Hui, Zhang Shangjian, Zhang Rixin, Shen Shang, Yan Chuanhua. Changes in pulmonary arterial pressure during acute respiratory distress syndrome caused by injection of oleic acid in rabbits. Acta Physiol Sin 1986; 38 (3): (in Chinese with English abstract).