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猫颈动脉区压力和化学感受性刺激对孤束核自发放电的影响

骆鸿, 王志安, 何瑞荣

河北医学院基础医学研究所生理研究室. 河北

摘要

对27只氯醛糖和氨基甲酸乙酯麻醉的猫观察了选择性激活颈动脉压力和化学感受器对孤束核(NTS)及其附近区域单位放电的影响。共记录到103个对颈动脉压力感受器激活(新福林1—2μg/kg,iv)和/或颈动脉化学感受器激活(尼古丁,5—20μg,注入甲状腺动脉)起反应的单位,其中81个位于NTS,在这些单位中,14个仅对化学感受器激活起反应(10个兴奋和4个抑制),44个以各种组合形式对化学和压力感受性刺激都起反应,23个仅对压力感受器刺激起反应(18个兴奋和5个抑制)。

关键词： 颈动脉化学感受器; 颈动脉压力感受器; 孤束核; 单位放电; 延髓尾端

Effects of stimulation of carotid baro-and chemoreceptor on single unit activity of nucleus iractus solitarius in the cat

Luo Hong, Wang Zhian, Ho Shiuyong

Department of Physiology, Institute of Basic Medicine, Hebei Medical College. Hebei, China

Abstract

The effects of selective activation of carotid baro- and chemoreceptor on the
single unit activity in or nearly the nucleus tractus solitarius (NTS) of caudal medulla were studied in 27 cats under a-chloralose and urethane anesthesia. Of the 103 single units with change of discharge frequency in response to activation of carotid baroreceptor (phenylephrine, 1-2 #mu#g/kg, iv) and/or chemoreceptor (nicotine,5-20 #mu#g, injected into the thyroid artery), 81 were located in NTS, among which 14 responded only to chemoreceptor activation (10 excited and 4 inhibited), 44 with various patterns to both baro- and chemoreceptor activation, and 23 only to baroreceptor activation (18 excited and 5 inhibited). Topographically, the units responsive to both baro- and chemoreceptor activation primarily located in the caudal part of the NTS and the units responsive only to chemoreceptor activation were mainly in the ventrolateral part of NTS, while the remaining units were sparsely distributed in parahypoglossal area,paramedian reticular nucleus and ventral caudal medulla.
In alt the responsive units of the NTS, 67 responded to baroreceptor activation
(excitatory versus inhibitory being 46 to 21) and 58 responded to chemoreceptor
activation (excitatory versus inhibitory being 36 to 22). The significance of the various responsive units of NTS to baro-and chemoreceptor activation was discussed.

Key words: Caretid chemoreceptor;Carotid baroreceptor;Nucleus tractus solitarius;Single unit discharge;Candal medulla

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引用本文：

骆鸿, 王志安, 何瑞荣. 猫颈动脉区压力和化学感受性刺激对孤束核自发放电的影响[J]. 生理学报 1987; 39 (5): .

Luo Hong, Wang Zhian, Ho Shiuyong. Effects of stimulation of carotid baro-and chemoreceptor on single unit activity of nucleus iractus solitarius in the cat. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).