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摘要

Effect of cooling or ablation of the culmen of cerebellar vermis on “stepping automatism”in guinea pigs

Abstract

The present paper concerns an investigation of the effect of partial cooling or
ablation of the culmen of the cerebellar vermis on “stepping automatism” inntact guinea pigs. Regular "stepping automatism" was induced via our recently reported SIS (Substances capable of Inducing Stepping)[(4-R-2,2,5,5-tetrakis (trifluoromethyl)-imidazoline) ]I1一’〕.Results show that partial cooling or ;ablation of the culmen (y and 1Y lobules) and centralis(ta, b) of the cerebellar vermis significantly facilitated SIS-induced "stepping automatism" in guinea ;pigs. Cooling of the cerebellum could only modulate but not trigger stepping movements. This modulation was most prominent in those guinea pigs exhibiting weak "stepping automatism". It is worthy of note that the culmen of cerebellar vermis modulated both left and right forelimbs simultaneously, whereas the lateral part of culmen of cerebellar vermis and hemisphere predominantly modulated ipsilateral forelimb. Results show that when the interfacial temperature between the cooling probe and tentorium cerebelli was appropriate (5-00C), the effects of partial ablation could be very largely mimicked.

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引用本文：

. [J]. 生理学报 1987; 39 (5): .

. Effect of cooling or ablation of the culmen of cerebellar vermis on “stepping automatism”in guinea pigs. Acta Physiol Sin 1987; 39 (5): (in Chinese with English abstract).