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酪氨酸对男子血清促性腺激素和睾酮浓度的影响

倪江, 高而威, 程治平

哈尔滨医科大学生殖内分泌研究室. 黑龙江

摘要

给成年男子(n=5)口服酪氨酸300mg/日,共6天,第四天肌注 LRH-A 150μg/人,用RIA 法测定其血清 LH、FSH 和睾酮浓度。与对照组(n=5)相比,酪氨酸对 LH 和 FSH 的基础水平和 LRH-A 诱发的 LH 峰和 FSH 峰均无明显影响。睾酮的基础水平稍有升高,而酪氨酸对 LRH-A 引起的睾酮水平升高有明显的抑制作用。结果提示,酪氨酸可不通过垂体而直接作用于睾丸以影响睾酮的分泌。

关键词： L-酪氨酸; 黄体生成素(LH); 卵泡刺激素(FSH); 睾酮; 促性腺激素

Effect of tyrosine on serum concentrations of lh, fsh and testosterone in adult men

Ni Jiang, Gao Erwei, Cheng Chiping

The Reproductive Endocrinology Laboratory, Harbin Medical University. Heilongjiang, China

Abstract

The effect of tyrosine on serum concentrations of LH, FSH and testosterone (T) in 10 adult young men was studied in order to find out whether tyrosine affects the secretion of gonadotropins by the pituitary. Five subjects took L-tyrosine orally 100mg t.i.d. for 6 days, and five served as control. Blood samples were taken between 8:00-9:00 each day for the determination of LH, FSH and T by RIA. On the morning of the fifth day, all subjects were injected intramuscularly with 150IAg LRH-A. Blood samples were then obtained 15, 30, 45, 60, 90, 120, 240 min and 24 h after the injection. The results showed that tyrosine did not alter both the basic levels and the LRH-A-stimulated rise of serum LH and FSH, but was capable of increasing the basic secretion of T slightly. However, tyrosine significantly inhibited the increase in T concentration which was expected to occur after the LRH-A injection. It is, therefore, believed that tyrosine may exert some inhibitory effect.

Key words: L-tyrosiae;LH;FSH;Gonadotropias;Testosterone

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引用本文：

倪江, 高而威, 程治平. 酪氨酸对男子血清促性腺激素和睾酮浓度的影响[J]. 生理学报 1985; 37 (3): .

Ni Jiang, Gao Erwei, Cheng Chiping. Effect of tyrosine on serum concentrations of lh, fsh and testosterone in adult men. Acta Physiol Sin 1985; 37 (3): (in Chinese with English abstract).