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家兔油酸型呼吸窘迫综合征呼吸运动变化的机制

倪慧, 金龙铉, 滕忆岭

南京医学院生理学教研室. 江苏

摘要

该文介绍家兔实验性呼吸窘迫综合征时呼吸功能的变化。静脉注射油酸后呼吸频率迅速增加,肺通气量则经历三个时相的变化,依次为最初通气增大期、延迟通气增大期和通气不足期。胸廓呼吸运动的幅度随着时间的延长逐渐加大而潮气量则逐渐减少。O_(2)吸收率及 CO_(2)排出率在通气不足期显著减少。血气分析提示,在通气增大期有呼吸性碱中毒,至通气不足期出现酸中毒。动脉血 PO_(2)在注射油酸后20min 时尚能维持在80mmHg 左右,以后则明显下降。切断双侧迷走神经后再注射油酸,呼吸不再增快,最初通气增大期显著减弱,而延迟通气增大期和通气不足期照常发生。

关键词： 呼吸窘迫综合征; 油酸; 通气量; O_(2)吸收率; CO_(2)排出率; 迷走神经; 窦神经; 低氧血症

Mechanism underlying the changes in respiratory movement in respiratory distress syndrome caused by oi etc acid in rabbits

Ni Hui, Jin Longxuan, Tend Yiling

Department of Physiology, Nanjing Medical College. Jiangsu, China

Abstract

Respiratory distress syndrome (RDS) produced experimentally in rabbits by intravenous injection of oleic acid was characterized by phasic changes in pulmonary ventilation, i.e., an initial hyperventilatory phase, a delayed hyperventilatory phase and finally followed by a hypoventilatory phase. The amplitude of respiratory movement shown by intrathoracic pressure curves underwent a consistent and gradual increase with concomittent reduction of tidal volume. Marked drop in O_(2) absorption rate and CO_(2) output rate occurred only during the hypoventilatory phase. In accordance with the shift of respiratory pattern, respiratory alkalosis and acidosis shown by blood gas analysis were observed in the hyperventilatory and hypoventilatory phases respectively. Arterial PO_(2) was maintained above 80 mmHg in the initial 20 minutes after injection and declined subsequently. The initial hyperventilatory phase disappeared after bilateral vagotomy while the late hyperventilatory phase and hypoventilatory phase still persisted. In contrast to this, after bilateral sinus denervation, the initial hyperventilatory response to injection of oleic acid was still present, while the late hyperventilatory phase disappeared. Therefore, it is assumed that the tachypnea and the early phase of hyperventilation following injection of oleic acid are mainly initiated by way of the vagus nerve, while the late hyperventilatory phenomenon is due to anoxemia involving peripheral chemoreceptors.

Key words: Respiratory distress syndrome;Oleic acid;Ventilation;O_(2) absorption rate;CO_(2) output rate;Vagal nerve;Sinus nerve;Anoaemia

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引用本文：

倪慧, 金龙铉, 滕忆岭. 家兔油酸型呼吸窘迫综合征呼吸运动变化的机制[J]. 生理学报 1985; 37 (3): .

Ni Hui, Jin Longxuan, Tend Yiling. Mechanism underlying the changes in respiratory movement in respiratory distress syndrome caused by oi etc acid in rabbits. Acta Physiol Sin 1985; 37 (3): (in Chinese with English abstract).