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缺氧对离体猫心乳头肌力学的影响

丁报春, 李云霞, 杨录化

湖南医学院生理学教研室. 湖南

摘要

该文研究缺氧对离体猫心乳头肌力学的影响,以探讨缺血性心肌损伤中缺氧这一因素所起的作用。结果表明:①-dT/dt max/Tmax(舒张指标之一)在缺氧 lmin 时明显降低(P<0.05),而所有收缩指标无变化。②缺氧4min 时,-dT/dt max 降低16.7%(P<0.01),而+dT/dt max 在缺氧7min 时才降低16.6%(P<0.05)。③在缺氧4min 时,所有舒张指标已发生显著的变化,而所有收缩指标在缺氧7min 时才有明显改变。缺氧对离体猫心乳头肌的收缩过程和舒张过程都有影响,但是舒张过程的变化较之收缩过程出现更早,且较明显。

关键词： 缺氧; 乳头肌; 舒张时间; 张力发展(或降低)的最大速率

Effects of hypoxia on mechanical properties of isolated cat papillary muscle

Ding Baochung, Li Yunxia, Yang Luhua

Defiartment of Physiology, Hunan Medical College. Hunan, China

Abstract

The mechanical properties of isolated cat papillary muscle were investigated during hypoxia and after reoxygenation. The results showed that -dT/dt max/T max, one of the relaxation parameters, decreased significantly after 1 min hypoxia, while all the other contraction parameters remained unchanged. -dT/dt max decreased to 16.7% (P<0.01) after 4 min hypoxia, while the time needed for -dT/dt max decreased to the same extent (16.6%, P<0.05) was 7 min. All relaxation parameters changed significantly for a point of 4 min hypoxia, but the changes of contraction parameters were delayed only after 7 min hypoxia. It is concluded that both contraction and relaxation processes of isolated cat papillary muscle are affected by hypoxia, in which the change of relaxation process begins to appear earlier and more prominent than that of contraction process.

Key words: Hyposia;Papillary muscle;Relaxation time;dT/dt max and -dT/dt max/T max

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引用本文：

丁报春, 李云霞, 杨录化. 缺氧对离体猫心乳头肌力学的影响[J]. 生理学报 1985; 37 (3): .

Ding Baochung, Li Yunxia, Yang Luhua. Effects of hypoxia on mechanical properties of isolated cat papillary muscle. Acta Physiol Sin 1985; 37 (3): (in Chinese with English abstract).