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植物油对大鼠应激性胃粘膜损伤的保护作用

郭燕世, 张建福

北京医学院基础医学研究所消化生殖生理研究室. 北京

摘要

将大鼠捆缚后置于4℃冰箱3h,造成应激性胃粘膜损伤,损伤程度用损伤指数表示:(1)在应激前3h 用0.5、1.0、2.0ml 的花生油灌胃,使损伤指数从对照的18.8—22.6降为6.8—7.0,P<0.01,但当花生油用量降至0.25ml 时,其保护作用不明显;(2)在应激前0.5、1.5、2.5和3.5h用1.0ml 花生油灌胃,也均有保护作用,(3)菜籽油或油酸有类似花生油的抗胃粘膜损伤作用,而且油酸的作用比花生油更显著,但30%甘油却无效;(4)将1.0ml 花生油注入空肠,具有与灌胃相似的保护作用;(5)在大鼠应激前1.5h 肌注消炎痛(10mg/kg),并不能阻断花生油的保护作用。

关键词： 花生油; 脂肪酸; 应激性胃溃疡; 细胞保护作用; 前列腺素

Cytoprotective effect of vegetable oil on stress-induced gastric mucosal damage in rats

Guo Yanshi, Zhang Jianfu

Research Laboratory in Physiology of Digestion and Reproduction, Institute of Basic Medical Science, Beijing Medical College. Beijing, China

Abstract

The effect of vegetable oil on gastric mucosal damage induced by cold-restraint stress in rats was studied. The results were as follows: (1) Peanut oil administered orally in doses of 0.5, 1.0 and 2.0 ml, 3 hours before stress may significantly inhibit the development of gastric mucosal damage, but lower dose (0.25ml) was without effect. (2) The cytoprotective effect of peanut oil administered orally 0.5, 1.5, 2.5 and 3.5 hours before stress was also obvious. (3) Rapseed oil and oleic acid also exerted a significantly cytoprotective effect similar to that of peanut oil, but 30%, glycerin did not. (4) The action of peanut oil introduced into jejunum was the same as that administered orally. (5) Indomcthacin could not abolish the cytoprotection of peanut oil. From the above results it is suggested that vegetable oil may exert a significant cytoprotective effect on stress-induced gastric mucosal damage. This effect might be produced by the fatty acid component of the oil acting at proximal part of the small intestine. The mechanism of this effect remains to be shown, but it does not seem to be mediated by prostaglandins.

Key words: Peanut oil;Fatty acid;Stress ulcer;Cytoprotection;Prostaglandin

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引用本文：

郭燕世, 张建福. 植物油对大鼠应激性胃粘膜损伤的保护作用[J]. 生理学报 1985; 37 (2): .

Guo Yanshi, Zhang Jianfu. Cytoprotective effect of vegetable oil on stress-induced gastric mucosal damage in rats. Acta Physiol Sin 1985; 37 (2): (in Chinese with English abstract).